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51276-47-2

51276-47-2 structure
51276-47-2 structure
  • Name: Glufosinate
  • Chemical Name: phosphinothricin
  • CAS Number: 51276-47-2
  • Molecular Formula: C5H12NO4P
  • Molecular Weight: 181.12700
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2018-03-17 08:00:00
  • Modify Date: 2024-01-04 13:09:01
  • Glufosinate, a phosphinic acid analogue of glutamic acid, is a herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate exerts neurotoxic activity[1][2].

Name phosphinothricin
Synonyms 2-amino-4-(hydroxymethylphosphinyl)butyric acid
(2RS)-2-amino-4-[hydroxy(methyl)phosphinoyl]butyric acid
4-[hydroxy(methyl)phosphinoyl]-DL-homoalanine
2-amino-4-(hydroxymethylphosphinyl)butanoic acid
glufosinate
Description Glufosinate, a phosphinic acid analogue of glutamic acid, is a herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate exerts neurotoxic activity[1][2].
Related Catalog
In Vitro Glufosinate (1-100 μM; 12DIV) disrupts cell-cell adhesion in differentiated V-SVZ neural stem cells (NSCs)[2]. Glufosinate (1-100 μM; 12DIV) significantly decreases Celsr2 gene expression at 100 μM[2]. Glufosinate impairs ependymal cell capability to synthetize cilia[2].
In Vivo Glufosinate (10-250 mg/kg; gavage; Daily; on days 6-15 of gestation) indicates maternal toxicity in the groups given 50 or 250 mg/kg in Wistar rats[3]. The Elimination of Glufosinate (oral intubation) in the blood takes place with a half-life of less than 4 hours in male and female rats[3].
References

[1]. Áy Z, et al. The effect of high concentrations of glufosinate ammonium on the yield components of transgenic spring wheat (Triticum aestivum L.) constitutively expressing the bar gene. ScientificWorldJournal. 2012;2012:657945.

[2]. Feat-Vetel J, et al. Multiple effects of the herbicide glufosinate-ammonium and its main metabolite on neural stem cells from the subventricular zone of newborn mice. Neurotoxicology. 2018 Dec;69:152-163.

[3]. Ebert E, et al. Summary of safety evaluation toxicity studies of glufosinate ammonium. Food Chem Toxicol. 1990 May;28(5):339-49.

Density 1.378 g/cm3
Boiling Point 519.1ºC at 760 mmHg
Melting Point 230ºC
Molecular Formula C5H12NO4P
Molecular Weight 181.12700
Flash Point 267.7ºC
Exact Mass 181.05000
PSA 110.43000
LogP 0.38890
Index of Refraction 1.5
Hazard Codes Xn
HS Code 2931900090
Precursor  0

DownStream  1

HS Code 2931900090
Summary 2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%