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77182-82-2

77182-82-2 structure
77182-82-2 structure
  • Name: Glufosinate ammonium
  • Chemical Name: glufosinate-ammonium
  • CAS Number: 77182-82-2
  • Molecular Formula: C5H15N2O4P
  • Molecular Weight: 215.18800
  • Catalog: Organic raw materials Organic phosphine compound
  • Create Date: 2018-09-07 14:37:34
  • Modify Date: 2024-01-02 11:24:57
  • Glufosinate ammonium, a phosphinic acid analogue of glutamic acid, is an herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate ammonium exerts neurotoxic activity[1][2].
Name glufosinate-ammonium
Synonyms Glufosinate Ammonium
2-Amino-4-(hydroxymethylphosphinyl)butyric acid ammonium salt
2-Amino-4-(hydroxymethylphosphinyl)butanoic acid, monoammonium salt
DL-Phosphinothricin, monoammonium salt
2-Amino-4-(hydroxymethylphosphinyl)butanoic acid monoammonium salt
2-Amino-4-[hydroxy(methyl)phosphoryl]butanoic acid ammoniate (1:1)
Glufosinate ammonium salt
Ammonium (3-amino-3-carboxypropyl)methylphosphinate
ammonium (2RS)-2-amino-4-(methylphosphinato)butyric acid
Monoammonium 2-amino-4-(hydroxymethylphosphinyl)butanoate
Ammonium 2-amino-4-(hydroxymethylphosphinyl)butyrate
Basta
Monoammonium 4-[hydroxy(methyl)phosphinoyl]-DL-homoalaninate
2-Amino-4-[hydroxy(methyl)phosphoryl]butanoic acid ammoniate
QVYZ2PQO&1 &&(DL) Form NH4 Salt
Ammonium (DL-homoalanine-4-yl)methylphosphinate
Glufosinate-ammonium
MFCD00055562
Butanoic acid, 2-amino-4-(hydroxymethylphosphinyl)-, ammonium salt
Ammonium 2-amino-4-[hydroxy(methyl)phosphoryl]butanoate
glufosinate-ammonum
EINECS 278-636-5
Description Glufosinate ammonium, a phosphinic acid analogue of glutamic acid, is an herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate ammonium exerts neurotoxic activity[1][2].
Related Catalog
In Vitro Glufosinate ammonium (1-100 μM; 12DIV) disrupts cell-cell adhesion in differentiated V-SVZ neural stem cells (NSCs)[2]. Glufosinate ammonium (1-100 μM; 12DIV) significantly decreases Celsr2 gene expression at 100 μM[2]. Glufosinate ammonium impairs ependymal cell capability to synthetize cilia[2]. RT-PCR[2] Cell Line: Ependymal cells Concentration: 1, 3, 10, 100 μM Incubation Time: During 12DIV (NSCs-to-ependymal cells time point) Result: Significantly decreased Celsr2 gene expression at 100 μM.
In Vivo Glufosinate ammonium (10-250 mg/kg; gavage; Daily; on days 6-15 of gestation) indicates maternal toxicity in the groups given 50 or 250 mg/kg in Wistar rats[3]. The Elimination of Glufosinate ammonium (oral intubation) in the blood takes place with a half-life of less than 4 hours in male and female rats[3].
References

[1]. Áy Z, et al. The effect of high concentrations of glufosinate ammonium on the yield components of transgenic spring wheat (Triticum aestivum L.) constitutively expressing the bar gene. ScientificWorldJournal. 2012;2012:657945.

[2]. Feat-Vetel J, et al. Multiple effects of the herbicide glufosinate-ammonium and its main metabolite on neural stem cells from the subventricular zone of newborn mice. Neurotoxicology. 2018 Dec;69:152-163.

[3]. Ebert E, et al. Summary of safety evaluation toxicity studies of glufosinate ammonium. Food Chem Toxicol. 1990 May;28(5):339-49.
Boiling Point 519.1ºC at 760 mmHg
Melting Point 210°C
Molecular Formula C5H15N2O4P
Molecular Weight 215.18800
Flash Point 100 °C
Exact Mass 215.10300
PSA 116.09000
LogP 0.24480
Stability Stable. Incompatible with strong oxidizing agents.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
EK7713600
CHEMICAL NAME :
Butanoic acid, 2-amino-4-(hydroxymethylphosphinyl)-, monoammonium salt
CAS REGISTRY NUMBER :
77182-82-2
LAST UPDATED :
199710
DATA ITEMS CITED :
14
MOLECULAR FORMULA :
C5-H11-N-O4-P.H4-N
MOLECULAR WEIGHT :
198.19

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
1600 uL/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes
REFERENCE :
JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988- Volume(issue)/page/year: 7,47,1994
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
1850 mg/kg
TOXIC EFFECTS :
Behavioral - coma Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes
REFERENCE :
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 36,17,1994
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1620 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C154,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A810,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
83 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 28,339,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
61 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 28,339,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
416 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,458,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
82 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 28,339,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
88 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 28,339,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,458,1991 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
18200 mg/kg/13W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 28,339,1990
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
13978 mg/kg/13W-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic - changes in potassium Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 28,339,1990
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Danger
Hazard Statements H302 + H312 + H332-H360Fd-H373
Precautionary Statements P201-P260-P280-P301 + P312 + P330-P308 + P313
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xn:Harmful;
Risk Phrases R22
Safety Phrases 53-45
RIDADR 2588
RTECS EK7713600
Packaging Group III
Hazard Class 6.1(b)
HS Code 2931901917
51276-47-2 structure

51276-47-2

~%

77182-82-2 structure

77182-82-2

Literature: WO2008/138088 A2, ; Page/Page column 8-9 ;
Precursor  1

DownStream  1

HS Code 2931900090
Summary 2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

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