71109-09-6

71109-09-6 structure

Name: Vedaprofen
Chemical Name: vedaprofen
CAS Number: 71109-09-6
Molecular Formula: C₁₉H₂₂O₂
Molecular Weight: 282.37700
Catalog: analytical chemistry Standard Pharmacopoeia Standards and Magazine Standards
Create Date: 2018-09-13 21:05:27
Modify Date: 2024-01-11 04:01:37
Vedaprofen (Quadrisol) is a COX-1 selective nonsteroidal anti-inflammatory drug (NSAID) for serum TxB2 and exudate PGE2 inhibition [1]. Vedaprofen is a Escherichia coli (E. coli) sliding clamp (SC) inhibitor with the IC50 of 222 μM[2].

Name	vedaprofen
Synonyms	2-(4-cyclohexylnaphthalen-1-yl)propanoic acid 2-(4-cyclohexyl-1-naphthyl)propanoic acid acide cyclohexyl-4 naphtalene-1-propionique Vedaprofen 2-(4-cyclohexyl-1-naphthyl)propionic acid PM-150 vedaprofene Quadrisol

Description	Vedaprofen (Quadrisol) is a COX-1 selective nonsteroidal anti-inflammatory drug (NSAID) for serum TxB2 and exudate PGE2 inhibition [1]. Vedaprofen is a Escherichia coli (E. coli) sliding clamp (SC) inhibitor with the IC50 of 222 μM[2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-1
In Vitro	Vedaprofen inhibits horse serum TxB2 and horse exudate PGE2 with IC50s of 9±5 and 630±148 ng/mL, respectively[1].Vedaprofen inhibit the E. coli DNA polymerase III β subunit with antibacterial potency[2]. Vedaprofen shows high E. coli SC binding affinity (Ki=131 μM)[2].
In Vivo	Pharmacokinetic parameters of vedaprofen in dogs[3]. Intravenous dose (mg/kg) t1/2β (h) AUC0–48 h (h·ng/mL) AUC0–∞ (h·ng/mL) 0.5 16.8±2.2 8612±1135 9518±1223 Oral dose (mg/kg) t1/2β (h) Cmax (ng/mL) tmax (h) AUC0–48 h (h·ng/mL) AUC0–∞ (h·ng/mL) F0–∞ (%) 0.5 12.7±2.1 2739±277 0.63±0.14 7090±1311 7650±1348 86±7
References	[1]. P Lees, et al. PK-PD integration and PK-PD modelling of nonsteroidal anti-inflammatory drugs: principles and applications in veterinary pharmacology. J Vet Pharmacol Ther. 2004 Dec;27(6):491-502. [2]. Zhou Yin,et al. DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs. Chem Biol. 2014 Apr 24;21(4):481-487. [3]. M Hoeijmakers, et al. The pharmacokinetics of Vedaprofen and its enantiomers in dogs after single and multiple dosing. J Vet Pharmacol Ther. 2005 Jun;28(3):305-12.

Density	1.132g/cm3
Boiling Point	465.9ºC at 760 mmHg
Melting Point	150ºC
Molecular Formula	C₁₉H₂₂O₂
Molecular Weight	282.37700
Flash Point	362.5ºC
Exact Mass	282.16200
PSA	37.30000
LogP	5.07560
Index of Refraction	1.603
Storage condition	-20°C Freezer

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
RIDADR	NONH for all modes of transport

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