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259270-28-5

259270-28-5 structure
259270-28-5 structure
  • Name: FP-Biotin
  • Chemical Name: 10-[ethoxy(fluoro)phosphoryl]-N-[5-[5-(2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl)pentanoylamino]pentyl]decanamide
  • CAS Number: 259270-28-5
  • Molecular Formula: C27H50FN4O5PS
  • Molecular Weight: 592.75
  • Catalog: Research Areas Others
  • Create Date: 2017-04-01 08:00:41
  • Modify Date: 2025-08-21 18:53:44
  • FP-biotin is a potent organophosphorus toxicant, well-suited for searching for new biomarkers of organophosphorus toxicants exposure. FP-Biotin quantifies FAAH, ABHD6, and MAG-lipase activity. FP-biotin is used for studies with plasma because biotinylated peptides are readily purified by binding to immobilized avidin beads[1][2][3].

Name 10-[ethoxy(fluoro)phosphoryl]-N-[5-[5-(2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl)pentanoylamino]pentyl]decanamide
Synonyms FP-biotin
Description FP-biotin is a potent organophosphorus toxicant, well-suited for searching for new biomarkers of organophosphorus toxicants exposure. FP-Biotin quantifies FAAH, ABHD6, and MAG-lipase activity. FP-biotin is used for studies with plasma because biotinylated peptides are readily purified by binding to immobilized avidin beads[1][2][3].
Related Catalog
In Vitro FP-biotin has good reactivity with human AChE and BChE despite its large biotin group. FP-biotin is suitable for the proposed task of identifying organophosphorus toxicants reactive proteins[1].
References

[1]. Schopfer LM, et al. Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase. Chem Res Toxicol. 2005;18(4):747-754.

[2]. Baggelaar MP, et al. Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases. ACS Chem Biol. 2017;12(3):852-861.

[3]. Grigoryan H, et al. Covalent binding of the organophosphorus agent FP-biotin to tyrosine in eight proteins that have no active site serine. Chem Biol Interact. 2009;180(3):492-498.

Density 1.125g/cm3
Boiling Point 851.3ºC at 760 mmHg
Molecular Formula C27H50FN4O5PS
Molecular Weight 592.75
Flash Point 468.6ºC
Exact Mass 592.32200
PSA 171.21000
LogP 7.08420
Vapour Pressure 2.82E-29mmHg at 25°C
Index of Refraction 1.497
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