FP-Biotin

Modify Date: 2024-01-13 11:08:32

FP-Biotin Structure
FP-Biotin structure
Common Name FP-Biotin
CAS Number 259270-28-5 Molecular Weight 592.75
Density 1.125g/cm3 Boiling Point 851.3ºC at 760 mmHg
Molecular Formula C27H50FN4O5PS Melting Point N/A
MSDS N/A Flash Point 468.6ºC

 Use of FP-Biotin


FP-biotin is a potent organophosphorus toxicant, well-suited for searching for new biomarkers of organophosphorus toxicants exposure. FP-Biotin quantifies FAAH, ABHD6, and MAG-lipase activity. FP-biotin is used for studies with plasma because biotinylated peptides are readily purified by binding to immobilized avidin beads[1][2][3].

 Names

Name 10-[ethoxy(fluoro)phosphoryl]-N-[5-[5-(2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl)pentanoylamino]pentyl]decanamide
Synonym More Synonyms

 FP-Biotin Biological Activity

Description FP-biotin is a potent organophosphorus toxicant, well-suited for searching for new biomarkers of organophosphorus toxicants exposure. FP-Biotin quantifies FAAH, ABHD6, and MAG-lipase activity. FP-biotin is used for studies with plasma because biotinylated peptides are readily purified by binding to immobilized avidin beads[1][2][3].
Related Catalog
In Vitro FP-biotin has good reactivity with human AChE and BChE despite its large biotin group. FP-biotin is suitable for the proposed task of identifying organophosphorus toxicants reactive proteins[1].
References

[1]. Schopfer LM, et al. Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase. Chem Res Toxicol. 2005;18(4):747-754.

[2]. Baggelaar MP, et al. Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases. ACS Chem Biol. 2017;12(3):852-861.

[3]. Grigoryan H, et al. Covalent binding of the organophosphorus agent FP-biotin to tyrosine in eight proteins that have no active site serine. Chem Biol Interact. 2009;180(3):492-498.

 Chemical & Physical Properties

Density 1.125g/cm3
Boiling Point 851.3ºC at 760 mmHg
Molecular Formula C27H50FN4O5PS
Molecular Weight 592.75
Flash Point 468.6ºC
Exact Mass 592.32200
PSA 171.21000
LogP 7.08420
Vapour Pressure 2.82E-29mmHg at 25°C
Index of Refraction 1.497

 Synonyms

FP-biotin
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