113411-17-9
113411-17-9 structure
- Name: DIF-3
- Chemical Name: 1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one
- CAS Number: 113411-17-9
- Molecular Formula: C13H17ClO4
- Molecular Weight: 272.72500
- Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
- Create Date: 2016-10-17 15:00:26
- Modify Date: 2024-01-02 11:27:28
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DIF-3 reduces the expression levels of cyclin D1 and c-Myc by facilitating their degradation via activation of GSK-3β. DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in DLD-1 cells. DIF-3 exerts a strong antiproliferative effect on the human cervical cancer cell line HeLa by inducing cyclin D1 degradation and inhibiting cyclin D1 mRNA expression[1].
| Name | 1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one |
|---|---|
| Synonyms |
Differentiation-inducing factor 3
1-(3-Chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone DIF-3 1-(3-Chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone Differentiation-inducing factor 3 1-Hexanone,1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl) Dif-3 (dictyostelium) |
| Description | DIF-3 reduces the expression levels of cyclin D1 and c-Myc by facilitating their degradation via activation of GSK-3β. DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in DLD-1 cells. DIF-3 exerts a strong antiproliferative effect on the human cervical cancer cell line HeLa by inducing cyclin D1 degradation and inhibiting cyclin D1 mRNA expression[1]. |
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| Related Catalog | |
| References |
| Density | 1.24g/cm3 |
|---|---|
| Boiling Point | 416.9ºC at 760mmHg |
| Molecular Formula | C13H17ClO4 |
| Molecular Weight | 272.72500 |
| Flash Point | 205.9ºC |
| Exact Mass | 272.08200 |
| PSA | 66.76000 |
| LogP | 3.52280 |
| Vapour Pressure | 1.53E-07mmHg at 25°C |
| Index of Refraction | 1.551 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |