DIF-3

Modify Date: 2024-01-02 11:27:28

DIF-3 Structure
DIF-3 structure
Common Name DIF-3
CAS Number 113411-17-9 Molecular Weight 272.72500
Density 1.24g/cm3 Boiling Point 416.9ºC at 760mmHg
Molecular Formula C13H17ClO4 Melting Point N/A
MSDS Chinese USA Flash Point 205.9ºC

 Use of DIF-3


DIF-3 reduces the expression levels of cyclin D1 and c-Myc by facilitating their degradation via activation of GSK-3β. DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in DLD-1 cells. DIF-3 exerts a strong antiproliferative effect on the human cervical cancer cell line HeLa by inducing cyclin D1 degradation and inhibiting cyclin D1 mRNA expression[1].

 Names

Name 1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one
Synonym More Synonyms

 DIF-3 Biological Activity

Description DIF-3 reduces the expression levels of cyclin D1 and c-Myc by facilitating their degradation via activation of GSK-3β. DIF-3 inhibits Wnt/β-catenin signaling pathway-related proteins in DLD-1 cells. DIF-3 exerts a strong antiproliferative effect on the human cervical cancer cell line HeLa by inducing cyclin D1 degradation and inhibiting cyclin D1 mRNA expression[1].
Related Catalog
References

[1]. Naoya Kubokura , et al. Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo. J Pharmacol Sci. 2015 Apr;127(4):446-55.

 Chemical & Physical Properties

Density 1.24g/cm3
Boiling Point 416.9ºC at 760mmHg
Molecular Formula C13H17ClO4
Molecular Weight 272.72500
Flash Point 205.9ºC
Exact Mass 272.08200
PSA 66.76000
LogP 3.52280
Vapour Pressure 1.53E-07mmHg at 25°C
Index of Refraction 1.551

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3

 Articles15

More Articles
The requirement for DIF for prestalk and stalk cell formation in Dictyostelium discoideum: a comparison of in vivo and in vitro differentiation conditions.

Dev. Biol. 127(2) , 296-303, (1988)

In Dictyostelium discoideum stalk cell formation is induced by cyclic AMP and differentiation-inducing factor (DIF) when cells are plated in in vitro monolayers (Kay et al., 1979, Differentiation 13: ...

Extracellular signals and intracellular transduction pathways regulating Dictyostelium development.

Curr. Opin. Cell Biol. 1(6) , 1132-8, (1989)

Cytoplasmic acidification facilitates but does not mediate DIF-induced prestalk gene expression in Dictyostelium discoideum.

Dev. Biol. 140(1) , 182-8, (1990)

Stalk cell differentiation in Dictyostelium can be induced by the differentiation-inducing factor, DIF, or by conditions that decrease intracellular pH (pHi). We have investigated whether cytoplasmic ...

 Synonyms

Differentiation-inducing factor 3
1-(3-Chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone
DIF-3
1-(3-Chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone Differentiation-inducing factor 3
1-Hexanone,1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)
Dif-3 (dictyostelium)