919289-58-0
919289-58-0 structure
- Name: Ro 25-6981 hydrochloride
- Chemical Name: 4-[(1R,2S)-3-(4-Benzyl-1-piperidinyl)-1-hydroxy-2-methylpropyl]ph enol hydrochloride (1:1)
- CAS Number: 919289-58-0
- Molecular Formula: C22H30ClNO2
- Molecular Weight: 375.93
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
- Create Date: 2016-03-31 12:52:00
- Modify Date: 2026-07-01 11:17:06
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Ro 25-6981 hydrochloride is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 hydrochloride shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 hydrochloride has the potential for the research of parkinson's disease (PD)[1][2][3].
| Name | 4-[(1R,2S)-3-(4-Benzyl-1-piperidinyl)-1-hydroxy-2-methylpropyl]ph enol hydrochloride (1:1) |
|---|---|
| Synonyms |
[R-(R*,S*)]-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinropanol hydrochloride hydrate
[R-(R*,S*)]-ALPHA-(4-HYDROXYPHENYL)-BETA-METHYL-4-(PHENYLMETHYL)-1-PIPERIDINROPANOL HYDROCHLORIDE [R-(R*,S*)]-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinropanol hydrochloride Ro 25 6981 HCl Ro 1 hydrochloride hydrate 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol Ro 1 HCl Ro 256981 HCl |
| Description | Ro 25-6981 hydrochloride is a potent, selective and activity-dependent NR2B subunit specific NMDA receptor antagonist. Ro 25-6981 hydrochloride shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 hydrochloride has the potential for the research of parkinson's disease (PD)[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | Ro 25-6981 Hydrochloride (0.39-12.5 mg/kg; i.p.) induces contraversive rotations in 6-hydroxydopamine (6-OHDA)-lesioned rats without stimulating locomotion in normal rats[1]. Ro 25-6981 Hydrochloride (1,3 mg/kg; i.p.) exhibits age- and activation-dependent anticonvulsant action at early postnatal development in rats[2]. Ro 25-6981 Hydrochloride (800 µg; intrathecal injection) shows significant analgesic effects on incision pain in rats and effectively attenuated postoperative hyperalgesia induced by remifentanil[3]. |
| In Vivo | Ro 25-6981 Hydrochloride (0.39-12.5 mg/kg; i.p.) induces contraversive rotations in 6-hydroxydopamine (6-OHDA)-lesioned rats without stimulating locomotion in normal rats[1]. Ro 25-6981 Hydrochloride (1,3 mg/kg; i.p.) exhibits age- and activation-dependent anticonvulsant action at early postnatal development in rats[2]. Ro 25-6981 Hydrochloride (800 µg; intrathecal injection) shows significant analgesic effects on incision pain in rats and effectively attenuated postoperative hyperalgesia induced by remifentanil[3]. Animal Model: 6-OHDA-lesioned rats[1] Dosage: 0.39-12.5 mg/kg Administration: I.p. Result: Dose-dependently induced contraversive tight nose-to-tail rotations, and induced a weak ipsiversive circling response indicating a mild unspecific stimulatory action of the compound. Animal Model: Male albino rats of Wistar strain[2] Dosage: 1, 3 mg/kg Administration: I.p. Result: Caused a significant decrease of N1–P2 amplitude at higher stimulation intensities AT 3 mg/kg, and exhibited age- and activation-dependent anticonvulsant action at early postnatal development. |
| References |
| Molecular Formula | C22H30ClNO2 |
|---|---|
| Molecular Weight | 375.93 |
| Exact Mass | 375.19700 |
| PSA | 43.70000 |
| LogP | 4.75630 |
| Hazard Codes | Xi |
|---|