57641-66-4

57641-66-4 structure

Name: Bromo-PEG2-alcohol
Chemical Name: 2-(2-Bromoethoxy)ethanol
CAS Number: 57641-66-4
Molecular Formula: C₄H₉BrO₂
Molecular Weight: 169.01700
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-20 21:25:29
Modify Date: 2024-01-03 18:58:43
Bromo-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-(2-Bromoethoxy)ethanol
Synonyms	2-(2-bromoethoxy)benzoic aldehyde 2-(2'-bromoethoxy)ethanol 2'-Brom-2-hydroxy-diaethylaether 2-(2-Bromoethoxy)benzenecarbaldehyde 2-(2-Brom-aethoxy)-aethanol 2-(2-Brom-aethoxy)-benzaldehyd o-(2-bromoethoxy)benzaldehyde 2-(2-bromo-ethoxy)-benzaldehyde 2<(1-formyl-2-phenyl)oxy>ethylbromide 2-bromoethoxyethanol Bromo-PEG2-alcohol

Description	Bromo-PEG2-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Hazard Codes	C

111-46-6

~63%

57641-66-4

75-21-8

540-51-2

57641-66-4

Literature: DE670419 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 25, p. 865

75-21-8

540-51-2

57641-67-5

57641-66-4

Literature: DE670419 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 25, p. 867

107-21-1

106-93-4

57641-66-4

Literature: Annales de Chimie (Cachan, France), , vol. <3>67, p. 272

107-21-1

106-93-4

123-91-1

57641-67-5

Detail

Literature: Annales de Chimie (Cachan, France), , vol. <3>67, p. 272