302912-06-7

302912-06-7 structure

Name: Citric acid-13C3
Chemical Name: 2-hydroxypropane-1,2,3-tricarboxylic acid
CAS Number: 302912-06-7
Molecular Formula: C₆H₈O₇
Molecular Weight: 195.10100
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-03-11 08:00:00
Modify Date: 2024-01-11 16:03:49
Citric acid-13C3 is the 13C labeled Citric acid[1]. Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice[2][3][4].

Name	2-hydroxypropane-1,2,3-tricarboxylic acid
Synonyms	MFCD01321401 Citric acid-1,5-13C2

Description	Citric acid-13C3 is the 13C labeled Citric acid[1]. Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice[2][3][4].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Chen X, et al. Study on injury effect of food additive citric acid on liver tissue in mice. Cytotechnology. 2014 Mar;66(2):275-82. [3]. Chen X, Lv Q, Liu Y, Deng W. Effects of the food additive, citric acid, on kidney cells of mice. Biotech Histochem. 2015 Jan90(1):38-44. [4]. Ying TH, et al. Citric acid induces cell-cycle arrest and apoptosis of human immortalized keratinocyte cell line (HaCaT) via caspase- and mitochondrial-dependent signaling pathways. Anticancer Res. 2013 Oct33(10):4411-20.

Symbol	GHS05
Signal Word	Danger
Hazard Statements	H315-H318
Precautionary Statements	P280-P305 + P351 + P338
Hazard Codes	Xi
Risk Phrases	R41;R37/38
Safety Phrases	S26;S36
RIDADR	NONH for all modes of transport