331770-21-9

331770-21-9 structure

Name: Aurora Kinase Inhibitor II
Chemical Name: N-[4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenyl]benzamide
CAS Number: 331770-21-9
Molecular Formula: C₂₃H₂₀N₄O₃
Molecular Weight: 400.43000
Catalog: Signaling Pathways Cell Cycle/DNA Damage Aurora Kinase
Create Date: 2017-12-08 00:38:07
Modify Date: 2024-01-08 17:39:00
Aurora kinase inhibitor-2 is a selective and ATP-competitive Aurora kinase inhibitor with IC50s of 310 nM and 240 nM for Aurora A and Aurora B, respectively[1].

Name	N-[4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenyl]benzamide
Synonyms	quinazoline deriv. 1 Aurora Kinase Inhibitor II 4-(4'-Benzamidoanilino)-6,7-dimethoxyquinazoline Anilinoquinazoline1

Description	Aurora kinase inhibitor-2 is a selective and ATP-competitive Aurora kinase inhibitor with IC50s of 310 nM and 240 nM for Aurora A and Aurora B, respectively[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Aurora Kinase Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase
Target	Aurora A:310 nM (IC50) Aurora B:240 nM (IC50)
In Vitro	Aurora kinase inhibitor-2 (Compound 1) shows excellent levels of Aurora A enzyme inhibition and is also effective in an MCF7 cellular anti-proliferative assay (IC50 value of 1.25 µM)[2].
References	[1]. Andrew A Mortlock, et al. Progress in the development of selective inhibitors of aurora kinases. Curr Top Med Chem. 2005;5(8):807-21. [2]. Nicola M Heron, et al. SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1320-3.