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4213-45-0

4213-45-0 structure
4213-45-0 structure
  • Name: Quinacrine mustard dihydrochloride
  • Chemical Name: quinacrine mustard dihydrochloride
  • CAS Number: 4213-45-0
  • Molecular Formula: C23H30Cl5N3O
  • Molecular Weight: 541.76900
  • Catalog: Research Areas Others
  • Create Date: 2018-08-02 20:09:00
  • Modify Date: 2025-08-20 07:51:15
  • Quinacrine mustard dihydrochloride is a fluorochrome. Quinacrine mustard dihydrochloride as a polycyclic aromatic agent can be used as mutagenic agent induces the mutants of bacteria. Quinacrine mustard dihydrochloride induces cell cycle arrest at G2/M-phase. Quinacrine mustard dihydrochloride has the potential for the research of plant, animal, or human chromosomes[1][2][3].
Name quinacrine mustard dihydrochloride
Synonyms Quinacrine mustard dihydrochloride
N4,N4-Bis-(2-chlor-aethyl)-N1-(6-chlor-2-methoxy-acridin-9-yl)-1-methyl-butandiyldiamin,Dihydrochlorid
N1,N1-bis(2-chloroethyl)-N4-(6-chloro-2-methoxyacridin-9-yl)pentane-1,4-diamine dihydrochloride
EINECS 224-140-9
N4,N4-bis-(2-chloro-ethyl)-N1-(6-chloro-2-methoxy-acridin-9-yl)-1-methyl-butanediyldiamine,dihydrochloride
quinacrine mustard
Atabrine mustard dihydrochloride
ICR 10
3-chloro-7-methoxy-9-(1-methyl-4-(N,N-bis(2-chloroethyl)amino)butylamino)acridine dihydrochloride
1-N,1-N-bis(2-chloroethyl)-4-N-(6-chloro-2-methoxyacridin-9-yl)pentane-1,4-diamine,dihydrochloride
Mepacrine mustard dihydrochloride
Description Quinacrine mustard dihydrochloride is a fluorochrome. Quinacrine mustard dihydrochloride as a polycyclic aromatic agent can be used as mutagenic agent induces the mutants of bacteria. Quinacrine mustard dihydrochloride induces cell cycle arrest at G2/M-phase. Quinacrine mustard dihydrochloride has the potential for the research of plant, animal, or human chromosomes[1][2][3].
Related Catalog
In Vitro Quinacrine mustard dihydrochloride (5 µg/ml) can be used for the DNA strain of plant, animal, or human chromosomes[1]. Quinacrine mustard dihydrochloride (28 µM) increases the number ofmutants that appeared after an exposure of bacteria[2]. quinacrine mustard dihydrochloride (0.2 µM; 4h) induces cell cycle arrest at G2+M-phase in HL-60 cells[3]. Caffeine (5 mM) prevents the cytotoxic action of quinacrine mustard dihydrochloride (0.2 µM; 4h) in HL-60 cells[3]. Cell Cycle Analysis[3] Cell Line: HL-60 cells Concentration: 0.2 µM Incubation Time: 4 h Result: Induced cell cycle arrest at G2+M-phase with the accumulation of cells in this compartment by 50%.
References

[1]. Caspersson T, et al. Fluorescent labeling of chromosomal DNA: superiority of quinacrine mustard to quinacrine. Science. 1970 Nov 13;170(3959):762.

[2]. Piosik J, et al. Alleviation of mutagenic effects of polycyclic aromatic agents (quinacrine mustard, ICR-191 and ICR-170) by caffeine and pentoxifylline. Mutat Res. 2003 Sep 29;530(1-2):47-57.

[3]. Kapuscinski J, et al. The modulation of the DNA-damaging effect of polycyclic aromatic agents by xanthines. Part I. Reduction of cytostatic effects of quinacrine mustard by caffeine. Biochem Pharmacol. 2002 Feb 15;63(4):625-34.

Density 1.271g/cm3
Boiling Point 574.1ºC at 760 mmHg
Melting Point 150 °C
Molecular Formula C23H30Cl5N3O
Molecular Weight 541.76900
Flash Point 301ºC
Exact Mass 539.08300
PSA 37.39000
LogP 8.08720
Index of Refraction 1.632

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AR7580000
CHEMICAL NAME :
Acridine, 9-(4-bis(2-chloroethyl)amino-1-methylbutylamino)-6-ch loro-2-methoxy-, dihydrochloride
CAS REGISTRY NUMBER :
4213-45-0
LAST UPDATED :
199710
DATA ITEMS CITED :
15
MOLECULAR FORMULA :
C23-H28-Cl3-N3-O.2Cl-H
MOLECULAR WEIGHT :
541.81
WISWESSER LINE NOTATION :
T C666 BNJ EG IMY3N2G2G LO1 &GH &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2700 ug/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
TYPE OF TEST :
Specific locus test
TYPE OF TEST :
Sex chromosome loss and nondisjunction

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
50 umol/kg
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 26,553,1974
Symbol GHS06 GHS08
GHS06, GHS08
Signal Word Danger
Hazard Statements H301-H317-H331-H334-H361
Precautionary Statements P261-P280-P301 + P310-P311
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes T+
Risk Phrases 46-23/25-42/43
RIDADR UN 3249
RTECS AR7580000
Packaging Group III
Hazard Class 6.1(b)
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