29976-75-8
29976-75-8 structure
- Name: 6-Methylflavone
- Chemical Name: 6-methyl-2-phenylchromen-4-one
- CAS Number: 29976-75-8
- Molecular Formula: C16H12O2
- Molecular Weight: 236.26500
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
- Create Date: 2018-02-21 08:00:00
- Modify Date: 2025-08-28 11:50:27
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6-methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors.
| Name | 6-methyl-2-phenylchromen-4-one |
|---|---|
| Synonyms |
6-methyl-2-phenyl-4H-1-benzopyran-4-one
MFCD00017461 2-phenyl-6-methylchromone 6-methyl-flavone 6-Methylflavone |
| Description | 6-methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors. |
|---|---|
| Related Catalog | |
| Target |
α1β2γ2L GABAA receptor, α1β2 GABAA receptor[1] |
| In Vitro | 6-methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors. 6-Methylflavone enhances the normal response to GABA at recombinant α1β2γ2L and α1β2 GABAA receptors (P<0.0001) at concentrations from 1 to 100 μM. 6-Methylflavone (60 μM) shifts the GABA dose-response curve to the left (n=4, F=16.38, P=0.0004), decreasing the mean EC50 at α1β2γ2L GABAA receptors by 33±5.4%[1]. |
| References |
| Density | 1.208g/cm3 |
|---|---|
| Boiling Point | 395.5ºC at 760mmHg |
| Melting Point | 119-122 °C (dec.)(lit.) |
| Molecular Formula | C16H12O2 |
| Molecular Weight | 236.26500 |
| Flash Point | 183.8ºC |
| Exact Mass | 236.08400 |
| PSA | 30.21000 |
| LogP | 3.76840 |
| Vapour Pressure | 1.83E-06mmHg at 25°C |
| Index of Refraction | 1.623 |
| Hazard Codes | Xi: Irritant; |
|---|---|
| Risk Phrases | 36/37/38 |
| Safety Phrases | S26-S36 |
| WGK Germany | 3 |
| HS Code | 2914399090 |
| HS Code | 2914399090 |
|---|---|
| Summary | 2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0% |