6-Methylflavone

Modify Date: 2025-08-28 11:50:27

Use of 6-Methylflavone

6-methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors.

Name	6-methyl-2-phenylchromen-4-one
Synonym	More Synonyms

Description	6-methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Natural Products >> Flavonoids Research Areas >> Neurological Disease
Target	α1β2γ2L GABAA receptor, α1β2 GABAA receptor[1]
In Vitro	6-methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors. 6-Methylflavone enhances the normal response to GABA at recombinant α1β2γ2L and α1β2 GABAA receptors (P<0.0001) at concentrations from 1 to 100 μM. 6-Methylflavone (60 μM) shifts the GABA dose-response curve to the left (n=4, F=16.38, P=0.0004), decreasing the mean EC50 at α1β2γ2L GABAA receptors by 33±5.4%[1].
References	[1]. Hall BJ, et al. Flumazenil-independent positive modulation of gamma-aminobutyric acid action by 6-methylflavone at human recombinant alpha1beta2gamma2L and alpha1beta2 GABAA receptors. Eur J Pharmacol. 2004 Apr 26;491(1):1-8.

HS Code	2914399090
Summary	2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

6-methyl-2-phenyl-4H-1-benzopyran-4-one

MFCD00017461

2-phenyl-6-methylchromone

6-methyl-flavone

6-Methylflavone

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Price: $55/10mM*1mLinDMSO

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