6-Methylflavone
6-Methylflavone structure
|
Common Name | 6-Methylflavone | ||
|---|---|---|---|---|
| CAS Number | 29976-75-8 | Molecular Weight | 236.26500 | |
| Density | 1.208g/cm3 | Boiling Point | 395.5ºC at 760mmHg | |
| Molecular Formula | C16H12O2 | Melting Point | 119-122 °C (dec.)(lit.) | |
| MSDS | N/A | Flash Point | 183.8ºC | |
Use of 6-Methylflavone6-methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 6-methyl-2-phenylchromen-4-one |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | 6-methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors. |
|---|---|
| Related Catalog | |
| Target |
α1β2γ2L GABAA receptor, α1β2 GABAA receptor[1] |
| In Vitro | 6-methylflavone is an activator of α1β2γ2L and α1β2 GABAA receptors. 6-Methylflavone enhances the normal response to GABA at recombinant α1β2γ2L and α1β2 GABAA receptors (P<0.0001) at concentrations from 1 to 100 μM. 6-Methylflavone (60 μM) shifts the GABA dose-response curve to the left (n=4, F=16.38, P=0.0004), decreasing the mean EC50 at α1β2γ2L GABAA receptors by 33±5.4%[1]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.208g/cm3 |
|---|---|
| Boiling Point | 395.5ºC at 760mmHg |
| Melting Point | 119-122 °C (dec.)(lit.) |
| Molecular Formula | C16H12O2 |
| Molecular Weight | 236.26500 |
| Flash Point | 183.8ºC |
| Exact Mass | 236.08400 |
| PSA | 30.21000 |
| LogP | 3.76840 |
| Vapour Pressure | 1.83E-06mmHg at 25°C |
| Index of Refraction | 1.623 |
| InChIKey | NOQJBXPAMJLUSS-UHFFFAOYSA-N |
| SMILES | Cc1ccc2oc(-c3ccccc3)cc(=O)c2c1 |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Hazard Codes | Xi: Irritant; |
|---|---|
| Risk Phrases | 36/37/38 |
| Safety Phrases | S26-S36 |
| WGK Germany | 3 |
| HS Code | 2914399090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2914399090 |
|---|---|
| Summary | 2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0% |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1100
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|
Name: qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in...
Source: NCGC
Target: TDP1 protein [Homo sapiens]
External Id: TDP1101
|
|
Name: A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
External Id: HMS979
|
|
Name: Ability to inhibit [3H]-Ro- 15-1788 binding to Gamma-aminobutyric acid A receptor alp...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit alpha-3
External Id: CHEMBL679569
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|
Name: qHTS for inhibitors of Vif-A3G interactions: Validation
Source: NCGC
Target: DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens]
External Id: VIFG001
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Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA
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Name: High-throughput screen for inhibitors of the GIV GBA-motif interaction with Galpha-i ...
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
External Id: HMS1303
|
|
Name: qHTS for Inhibitors of binding or entry into cells for Marburg Virus
Source: NCGC
Target: gene 4 small orf - Marburg virus
External Id: VSVM-OFFLINE
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|
Name: In vitro affinity against Benzodiazepine receptor binding to rat cortical membranes (...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit alpha-3
External Id: CHEMBL651177
|
|
Name: qHTS for Inhibitors of binding or entry into cells for Lassa Virus
Source: NCGC
Target: N/A
External Id: VSVL-OFFLINE
|
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 6-methyl-2-phenyl-4H-1-benzopyran-4-one |
| MFCD00017461 |
| 2-phenyl-6-methylchromone |
| 6-methyl-flavone |
| 6-Methylflavone |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the polar surface area (PSA) of 6-methyl-2-phenylchromen-4-one? |
| A: Polar surface area (PSA) of 6-methyl-2-phenylchromen-4-one is 30.21000. |
| Q: What English synonyms does 6-methyl-2-phenylchromen-4-one have? |
| A: English synonyms of 6-methyl-2-phenylchromen-4-one: 6-methyl-2-phenyl-4H-1-benzopyran-4-one, MFCD00017461, 2-phenyl-6-methylchromone, 6-methyl-flavone, 6-Methylflavone. |
| Q: What is the CAS number of 6-methyl-2-phenylchromen-4-one? |
| A: CAS number of 6-methyl-2-phenylchromen-4-one is 29976-75-8. |
| Q: What is the melting point of 6-methyl-2-phenylchromen-4-one? |
| A: Melting point of 6-methyl-2-phenylchromen-4-one is 119-122 °C (dec.)(lit.). |
| Q: What is the SMILES notation of 6-methyl-2-phenylchromen-4-one? |
| A: SMILES notation of 6-methyl-2-phenylchromen-4-one is Cc1ccc2oc(-c3ccccc3)cc(=O)c2c1. |
| Q: What is the molecular formula of 6-methyl-2-phenylchromen-4-one? |
| A: Molecular formula of 6-methyl-2-phenylchromen-4-one is C16H12O2. |
| Q: What is the molecular weight of 6-methyl-2-phenylchromen-4-one? |
| A: Molecular weight of 6-methyl-2-phenylchromen-4-one is 236.26500. |
| Q: What is the safety information for 6-methyl-2-phenylchromen-4-one? |
| A: Safety information for 6-methyl-2-phenylchromen-4-one: S26-S36. |
| Q: What is the boiling point of 6-methyl-2-phenylchromen-4-one? |
| A: Boiling point of 6-methyl-2-phenylchromen-4-one is 395.5ºC at 760mmHg. |
| Q: What is the English name of 6-methyl-2-phenylchromen-4-one? |
| A: The English name of 6-methyl-2-phenylchromen-4-one is 6-methyl-2-phenylchromen-4-one. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| Dayang Chem (Hangzhou) Co., Ltd. |