Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1H-Imidazole, 2-(2-benzofuranyl)-4,5-dihydro-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

72583-92-7

72583-92-7 structure

Name: 1H-Imidazole, 2-(2-benzofuranyl)-4,5-dihydro-
Chemical Name: 2-(1-benzofuran-2-yl)-4,5-dihydro-1H-imidazole
CAS Number: 72583-92-7
Molecular Formula: C₁₁H₁₀N₂O
Molecular Weight: 186.21
Catalog: Signaling Pathways GPCR/G Protein Imidazoline Receptor
Create Date: 2018-12-02 19:38:59
Modify Date: 2024-01-03 22:23:56
RX 801077 (2 BFI free base) is a selective imidazoline I2 receptor (I2R) agonist with a Ki value of 70.1 nM. RX 801077 shows anti-inflammation and neuroprotection. RX 801077 has the potential for the research of traumatic brain injury (TBI)[1][2].

Name	2-(1-benzofuran-2-yl)-4,5-dihydro-1H-imidazole
Synonyms	2-(2-Benzofuranyl)-2-imidazoline 2-benzofuran-2-yl-4,5-dihydro-1H-imidazole 2xcg 2-BFi (3H)2-Bfi 3H-2-(2-benzofuranyl)-2-imidazoline Tocris-0348 2-(2'-Imidazolinyl)benzofuran

Description	RX 801077 (2 BFI free base) is a selective imidazoline I2 receptor (I2R) agonist with a Ki value of 70.1 nM. RX 801077 shows anti-inflammation and neuroprotection. RX 801077 has the potential for the research of traumatic brain injury (TBI)[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Imidazoline Receptor Signaling Pathways >> GPCR/G Protein >> Imidazoline Receptor Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	Ki: 70.1 nM (imidazoline I2 receptor)[2]
In Vivo	RX 801077 (5、10、20 mg/kg；腹腔注射；每天两次，持续 3 天) 在创伤性脑损伤大鼠模型中抑制 NLRP3 炎性体诱导的炎症和坏死性凋亡[2]。 Animal Model: 280-300 g, Male adult Sprague-Dawley rats (TBI model)[2] Dosage: 5, 10, 20 mg/kg Administration: I.p.; twice daily for 3 days Result: Attenuated neurological deficits, brain edema, BBB permeability and cortical tissue loss in a rat model of TBI, reduced microglial activation, neutrophil infiltration, and proinflammatory cytokine IL-1β secretion, reduced the expression of RIP1 and RIP3 in neurons in the pericontusional cortex.
References	[1]. Carpéné C, et al. Inhibition of amine oxidase activity by derivatives that recognize imidazoline I2 sites. J Pharmacol Exp Ther. 1995 Feb;272(2):681-8. [2]. Ni H, et al. 2-BFI Provides Neuroprotection Against Inflammation and Necroptosis in a Rat Model of Traumatic Brain Injury. Front Neurosci. 2019 Jun 26;13:674.

Molecular Formula	C₁₁H₁₀N₂O
Molecular Weight	186.21
Exact Mass	186.07900
PSA	37.53000
LogP	1.54700

4265-16-1

72583-92-7

Literature: Sant' Anna, Gabriela da S.; Machado, Pablo; Sauzem, Patricia D.; Rosa, Fernanda A.; Rubin, Maribel A.; Ferreira, Juliano; Bonacorso, Helio G.; Zanatta, Nilo; Martins, Marcos A.P. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 2 p. 546 - 549

41717-32-2

107-15-3

72583-92-7

Literature: Anastassiadou; Baziard-Mouysset; Payard Synthesis, 2000 , # 13 p. 1814 - 1816

72583-86-9

107-15-3

72583-92-7

Literature: Shridhar,D.R. et al. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1979 , vol. 18, p. 254 - 256

Precursor 4
4265-16-1 41717-32-2 107-15-3 72583-86-9
DownStream 0

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