DC Chemicals Limited
China
Product Name: Amifostine thiol
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Purity: 98.0%
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31098-42-7

31098-42-7 structure

Name: Amifostine thiol
Chemical Name: wr-1065
CAS Number: 31098-42-7
Molecular Formula: C₅H₁₄N₂S
Molecular Weight: 134.24300
Catalog: Signaling Pathways Apoptosis MDM-2/p53
Create Date: 2018-12-27 23:09:01
Modify Date: 2025-08-24 19:28:23
Amifostine thiol (WR-1065) is an active metabolite of the cytoprotector Amifostine (HY-B0639). Amifostine thiol is a cytoprotective agent with radioprotective abilities. Amifostine thiol activates p53 through a JNK-dependent signaling pathway[1][2][3].

Name	wr-1065
Synonyms	N-2-mercaptoethyl-1,3-diaminopropane WR1065 Amifostine Thiol Dihydrochloride 2-(3-aminopropylamino)ethanethiol

Description	Amifostine thiol (WR-1065) is an active metabolite of the cytoprotector Amifostine (HY-B0639). Amifostine thiol is a cytoprotective agent with radioprotective abilities. Amifostine thiol activates p53 through a JNK-dependent signaling pathway[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> MDM-2/p53
Target	p53[2]
In Vitro	Amifostine thiol can reduce both the direct and delayed detrimental effects of both high and low-LET radiation exposures[1]. Amifostine thiol attenuates both the DNA damage and the G1-phase arrest induced by radiation[1]. Amifostine thiol (4 mM; 30 minutes) protects RKO36 cells from chromosomal damage and death induced by ionizing radiation[1]. Amifostine thiol (4 mM; 30 minutes) protects irradiated RKO36 cells from delayed genomic instability[1]. Amifostine thiol is cytotoxic to RKO36 cells at milimolar concentrations, especially after continuous treatment[1]. Amifostine thiol at 40 μM protects RKO36 cells from delayed genomic instability but not from cell death and immediate chromosomal damage[1]. Amifostine thiol activates JNK resulting in the phosphorylation of p53 at threonine 81[2]. Amifostine thiol affects phosphorylation of topoisomerase IIα leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells[3].
References	[1]. Jaroslaw Dziegielewski, et al. WR-1065, the Active Metabolite of Amifostine, Mitigates Radiation-Induced Delayed Genomic Instability. Free Radic Biol Med. 2008 Dec 15; 45(12): 1674–1681. [2]. Olivier Pluquet, et al. The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase. J Biol Chem. 2003 Apr 4;278(14):11879-87. J Biol Chem. 2003 Apr 4;278(14):11879-87. [3]. J. S. Murley, et al. WR-1065, an active metabolite of the cytoprotector amifostine, affects phosphorylation of topoisomerase IIα leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells. Cell Prolif. 1997 Jun; 30(6): 283–294.

Molecular Formula	C₅H₁₄N₂S
Molecular Weight	134.24300
Exact Mass	134.08800
PSA	76.85000
LogP	0.94580

HS Code	2930909090

420-12-2

109-76-2

31098-42-7

Literature: Wineman,R.J. et al. Journal of Organic Chemistry, 1962 , vol. 27, p. 4222 - 4226

Precursor 2
420-12-2 109-76-2
DownStream 0

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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