Amifostine thiol
Modify Date: 2024-01-08 16:21:51
Amifostine thiol structure
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Common Name | Amifostine thiol | ||
|---|---|---|---|---|
| CAS Number | 31098-42-7 | Molecular Weight | 134.24300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C5H14N2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Amifostine thiolAmifostine thiol (WR-1065) is an active metabolite of the cytoprotector Amifostine (HY-B0639). Amifostine thiol is a cytoprotective agent with radioprotective abilities. Amifostine thiol activates p53 through a JNK-dependent signaling pathway[1][2][3]. |
| Name | wr-1065 |
|---|---|
| Synonym | More Synonyms |
| Description | Amifostine thiol (WR-1065) is an active metabolite of the cytoprotector Amifostine (HY-B0639). Amifostine thiol is a cytoprotective agent with radioprotective abilities. Amifostine thiol activates p53 through a JNK-dependent signaling pathway[1][2][3]. |
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| Related Catalog | |
| Target |
p53[2] |
| In Vitro | Amifostine thiol can reduce both the direct and delayed detrimental effects of both high and low-LET radiation exposures[1]. Amifostine thiol attenuates both the DNA damage and the G1-phase arrest induced by radiation[1]. Amifostine thiol (4 mM; 30 minutes) protects RKO36 cells from chromosomal damage and death induced by ionizing radiation[1]. Amifostine thiol (4 mM; 30 minutes) protects irradiated RKO36 cells from delayed genomic instability[1]. Amifostine thiol is cytotoxic to RKO36 cells at milimolar concentrations, especially after continuous treatment[1]. Amifostine thiol at 40 μM protects RKO36 cells from delayed genomic instability but not from cell death and immediate chromosomal damage[1]. Amifostine thiol activates JNK resulting in the phosphorylation of p53 at threonine 81[2]. Amifostine thiol affects phosphorylation of topoisomerase IIα leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells[3]. |
| References |
| Molecular Formula | C5H14N2S |
|---|---|
| Molecular Weight | 134.24300 |
| Exact Mass | 134.08800 |
| PSA | 76.85000 |
| LogP | 0.94580 |
| HS Code | 2930909090 |
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~%
Amifostine thiol CAS#:31098-42-7 |
| Literature: Wineman,R.J. et al. Journal of Organic Chemistry, 1962 , vol. 27, p. 4222 - 4226 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |
| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
| N-2-mercaptoethyl-1,3-diaminopropane |
| WR1065 |
| Amifostine Thiol Dihydrochloride |
| 2-(3-aminopropylamino)ethanethiol |