432037-57-5
432037-57-5 structure
- Name: Teglarinad chloride
- Chemical Name: [4-[[N'-[6-(4-chlorophenoxy)hexyl]-N-cyanocarbamimidoyl]amino]pyridin-1-ium-1-yl]methyl 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethyl carbonate,chloride
- CAS Number: 432037-57-5
- Molecular Formula: C30H43Cl2N5O8
- Molecular Weight: 672.59700
- Catalog: Pharmaceutical intermediate Heterocyclic compound Pyridine compound Cyanopyridine
- Create Date: 2019-01-25 22:47:13
- Modify Date: 2024-04-06 12:01:04
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Teglarinad chloride (GMX1777) is a prodrug of GMX1778 (a nicotinamide phosphoribosyl transferase inhibitor). Teglarinad chloride exhibits antitumor activity in mice can be attributed to inhibition of NAMPT. Teglarinad chloride also enhances radiation efficacy, mediated by interference with DNA repair and antiangiogenesis[1][2].
| Name | [4-[[N'-[6-(4-chlorophenoxy)hexyl]-N-cyanocarbamimidoyl]amino]pyridin-1-ium-1-yl]methyl 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethyl carbonate,chloride |
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| Synonyms |
GMX1777
UNII-D6V5QYX9MZ Teglarinad chloride |
| Description | Teglarinad chloride (GMX1777) is a prodrug of GMX1778 (a nicotinamide phosphoribosyl transferase inhibitor). Teglarinad chloride exhibits antitumor activity in mice can be attributed to inhibition of NAMPT. Teglarinad chloride also enhances radiation efficacy, mediated by interference with DNA repair and antiangiogenesis[1][2]. |
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| Related Catalog | |
| In Vivo | GMX1777 (75 mg/kg; 24 h intravenous infusion) causes tumor regression in the IM-9 model, a small-cell lung cancer (SHP-77) model, and a colon carcinoma (HCT-116) model[2]. GMX1777 (50-100 mg/kg/d, i.m. for 5 d) with or without local tumor radiotherapy is effective for both FaDu and C666-1 tumors in vivo[1]. GMX1777 (25-400 mg/kg; 24 h intravenous infusion) is quickly converted to GMX1778 in plasma of mice with a half-life of GMX1777 less than 0.7 h[2]. Animal Model: CB17 SCID/SCID female mice bearing subcutaneous IM-9 multiple myeloma tumors[2] Dosage: 18.75, 35, 75 mg/kg Administration: A 24 h intravenous infusion Result: Induced a nearly complete regression of the tumors and a significant tumor growth delay at the dose of 75mg/kg. Reduced IM-9 tumor growth moderately At 37.5mg/kg. |
| References |
| Melting Point | 158-159ºC |
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| Molecular Formula | C30H43Cl2N5O8 |
| Molecular Weight | 672.59700 |
| Exact Mass | 671.24900 |
| PSA | 147.15000 |
| LogP | 5.10808 |
| Hazard Codes | Xi |
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