142479-62-7

142479-62-7 structure

Name: Gluten Exorphin C
Chemical Name: h-ypisl-oh
CAS Number: 142479-62-7
Molecular Formula: C₂₉H₄₅N₅O₈
Molecular Weight: 591.69600
Catalog: Peptides
Create Date: 2017-11-09 05:23:12
Modify Date: 2024-01-02 23:29:58
Gluten exorphin C is an opioid peptide derived from wheat gluten. Its IC50 values are 40 μM and 13.5 μM for μ opioid and δ opioid activities in the GPI and MVD assays, respectively.

Name	h-ypisl-oh
Synonyms	EXORPHIN C TRIFLUOROACETATE SALT Gluten Exorphin C

Description	Gluten exorphin C is an opioid peptide derived from wheat gluten. Its IC50 values are 40 μM and 13.5 μM for μ opioid and δ opioid activities in the GPI and MVD assays, respectively.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease Peptides
Target	IC50: 40 μM (μ opioid), 13.5 μM (δ opioid)[1]
In Vitro	Gluten exorphin C, a novel opioid peptide, is isolated from the pepsin-trypsin-chymotrypsin digest of wheat gluten. Gluten exorphin C is evaluated its opioid activities by the GPI and MVD assays and its receptor affinities by radioreceptor assays. Its IC50s are 40 μM and 13.5 μM in the GPI and the MVD assays, respectively. Gluten exorphin C has a structure quite different from any of the endogenous and exogenous opioid peptides ever reported in that the N terminal Tyr is the only aromatic amino acid. The analogs containing Tyr-Pro-X-Ser-Leu are synthesized to study its structure-activity relationship. Peptides in which X is an aromatic amino acid or an aliphatic hydrophobic amino acid has opioid activity[1].
References	[1]. Fukudome S, et al. Gluten exorphin C. A novel opioid peptide derived from wheat gluten. FEBS Lett. 1993 Jan 18;316(1):17-9.