69075-42-9

69075-42-9 structure

Name: 5-Ethynyl uridine
Chemical Name: 5-ethynyluridine
CAS Number: 69075-42-9
Molecular Formula: C₁₁H₁₂N₂O₆
Molecular Weight: 268.22300
Catalog: Research Areas Others
Create Date: 2018-08-27 09:10:51
Modify Date: 2026-07-06 11:00:11
5-Ethynyluridine (5-EU) is a potent cell-permeable nucleoside can be used to label newly synthesized RNA. 5-Ethynyluridine can be used for isolation and sequencing of nascent RNA from neuronal populations in vivo. 5-Ethynyluridine can be used to identify changes in transcription in vivo in nervous system disease models[1][2].

Name	5-ethynyluridine
Synonyms	Uridine, 5-ethynyl 5-Ethynyl-Ur 5-Ethynyl Uridine (5-EU) (CCT-1261) 5-Ethynyluridine ，E1255 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-ethynylpyrimidine-2,4(1H,3H)-dione 5-Ethynyluridine (5-EU) 5-Ethynyl Uridine (EU) 5-EU 5-Ethynyluridine (5-EU), Uridine analog EU(5-Ethynyl-uridine) 5-ETHYNYL URIDINE 5-Ethynyluridine, 10 mM in DMSO 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-ethynylpy 5-EU,neurons,purkinje cells,Inhibitor,nascent RNA,5 Ethynyluridine,5-Ethynyluridine,RNA transcripts,5Ethynyluridine,inhibit 5-ETHYNYL URIDINE; 1-((2R,3R,4S,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL)-5-ETHYNYLPY

Description	5-Ethynyluridine (5-EU) is a potent cell-permeable nucleoside can be used to label newly synthesized RNA. 5-Ethynyluridine can be used for isolation and sequencing of nascent RNA from neuronal populations in vivo. 5-Ethynyluridine can be used to identify changes in transcription in vivo in nervous system disease models[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vivo	5-Ethynyluridine (75 mM in PBS for 1 µl; intracerebellar injection ) shows a labeling of central nervous system cells in mouse[1]. 5-Ethynyluridine (330-750 µMol/g; i.p.) results in in labelling of nascent RNA in cells of multiple organs and tissues, but not in the central nervous system in mouse[1].
References	[1]. Van't Sant LJ, et al. In vivo 5-ethynyluridine (EU) labelling detects reduced transcription in Purkinje cell degeneration mouse mutants, but can itself induce neurodegeneration. Acta Neuropathol Commun. 2021 May 21;9(1):94. [2]. Jao CY, et al. Exploring RNA transcription and turnover in vivo by using click chemistry. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15779-84.