919936-70-2

919936-70-2 structure

Name: Pyridine, 4-[5-[[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]thio]-1,3,4-oxadiazol-2-yl]
Chemical Name: Pyridine, 4-[5-[[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]thio]-1,3,4-oxadiazol-2-yl]
CAS Number: 919936-70-2
Molecular Formula: C₁₆H₁₁N₅O₂S
Molecular Weight: 337.35600
Catalog: Signaling Pathways PI3K/Akt/mTOR GSK-3
Create Date: 2017-07-05 09:55:26
Modify Date: 2024-01-21 10:44:21
GS87 is a highly specific and potent GSK3 inhibitor with IC50s of 415nM and 521nM for GSK3α and GSK3β, respectively. GS87 induces differentiation of acute myeloid leukemia (AML) cell lines by effectively activating GSK3-dependent signaling components including MAPK signaling. GS87 modulates key GSK3 target proteins involved in cell proliferation and differentiation more effectively than Lithium and SB415285 (SB). GS87 has the potential for acting as a differentiation agent for non-promyelocytic AML research[1].

Name	Pyridine, 4-[5-[[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]thio]-1,3,4-oxadiazol-2-yl]
Synonyms	4-(5-([(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]sulfanyl)-1,3,4-oxadiazol-2-yl)pyridine

Description	GS87 is a highly specific and potent GSK3 inhibitor with IC50s of 415nM and 521nM for GSK3α and GSK3β, respectively. GS87 induces differentiation of acute myeloid leukemia (AML) cell lines by effectively activating GSK3-dependent signaling components including MAPK signaling. GS87 modulates key GSK3 target proteins involved in cell proliferation and differentiation more effectively than Lithium and SB415285 (SB). GS87 has the potential for acting as a differentiation agent for non-promyelocytic AML research[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
Target	GSK3α:415 nM (IC50) GSK3β:521 nM (IC50)
References	[1]. Sophia Hu, et al. A Novel Glycogen Synthase Kinase-3 Inhibitor Optimized for Acute Myeloid Leukemia Differentiation Activity. Mol Cancer Ther. 2016 Jul;15(7):1485-1494.