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855746-98-4

855746-98-4 structure
855746-98-4 structure
  • Name: Kurarinol
  • Chemical Name: kurarinol
  • CAS Number: 855746-98-4
  • Molecular Formula: C26H32O7
  • Molecular Weight: 456.52800
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease Tyrosinase
  • Create Date: 2016-04-04 20:21:35
  • Modify Date: 2025-08-21 10:31:01
  • Kurarinol is a flavanone found in the root of Sophora flavescens. Kurarinol is a competitive tyrosinase inhibitor, with IC50 of 0.1 μM for mushroom tyrosinase[1].
Name kurarinol
Description Kurarinol is a flavanone found in the root of Sophora flavescens. Kurarinol is a competitive tyrosinase inhibitor, with IC50 of 0.1 μM for mushroom tyrosinase[1].
Related Catalog
Target

IC50: 0.1 μM (mushroom tyrosinase)[1]

In Vitro Kurarinol manifests relatively low cytotoxic activity (EC50>30 μM)[1]. Kurarinol inhibits production of melanin in S. bikiniensis without affecting the growth of microorganism[1]. Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling (STAT3)[2].
In Vivo Kurarinol (20 mg/kg; p.o.; daily; for 3 days) reduced serum lipid levels in high-Cholesterol diet induced hyperlipidemic rats[3]. Animal Model: Male Sprague-Dawley rats (120-130g), hypercholesterolemic models[3] Dosage: 20 mg/kg Administration: Oral administration, daily, for 3 days Result: Decreased serum TC, TG, and LDL-C levels.
References

[1]. Y B Ryu, et al. Kurarinol, tyrosinase inhibitor isolated from the root of Sophora flavescens. Phytomedicine. 2008 Aug;15(8):612-8.

[2]. Guangwen Shu, et al. Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling. Toxicol Appl Pharmacol. 2014 Dec 1;281(2):157-65.

[3]. Hyun Young Kim, et al. Hypolipidemic effects of Sophora flavescens and its constituents in poloxamer 407-induced hyperlipidemic and cholesterol-fed rats. Biol Pharm Bull. 2008 Jan;31(1):73-8.
Molecular Formula C26H32O7
Molecular Weight 456.52800
Exact Mass 456.21500
PSA 116.45000
LogP 4.80440
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