Kurarinol

Modify Date: 2024-01-06 07:41:20

Kurarinol structure	Common Name	Kurarinol
	CAS Number	855746-98-4	Molecular Weight	456.52800
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₃₂O₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Kurarinol

Kurarinol is a flavanone found in the root of Sophora flavescens. Kurarinol is a competitive tyrosinase inhibitor, with IC50 of 0.1 μM for mushroom tyrosinase[1].

Name	kurarinol

Description	Kurarinol is a flavanone found in the root of Sophora flavescens. Kurarinol is a competitive tyrosinase inhibitor, with IC50 of 0.1 μM for mushroom tyrosinase[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase
Target	IC50: 0.1 μM (mushroom tyrosinase)[1]
In Vitro	Kurarinol manifests relatively low cytotoxic activity (EC50>30 μM)[1]. Kurarinol inhibits production of melanin in S. bikiniensis without affecting the growth of microorganism[1]. Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling (STAT3)[2].
In Vivo	Kurarinol (20 mg/kg; p.o.; daily; for 3 days) reduced serum lipid levels in high-Cholesterol diet induced hyperlipidemic rats[3]. Animal Model: Male Sprague-Dawley rats (120-130g), hypercholesterolemic models[3] Dosage: 20 mg/kg Administration: Oral administration, daily, for 3 days Result: Decreased serum TC, TG, and LDL-C levels.
References	[1]. Y B Ryu, et al. Kurarinol, tyrosinase inhibitor isolated from the root of Sophora flavescens. Phytomedicine. 2008 Aug;15(8):612-8. [2]. Guangwen Shu, et al. Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling. Toxicol Appl Pharmacol. 2014 Dec 1;281(2):157-65. [3]. Hyun Young Kim, et al. Hypolipidemic effects of Sophora flavescens and its constituents in poloxamer 407-induced hyperlipidemic and cholesterol-fed rats. Biol Pharm Bull. 2008 Jan;31(1):73-8.

Molecular Formula	C₂₆H₃₂O₇
Molecular Weight	456.52800
Exact Mass	456.21500
PSA	116.45000
LogP	4.80440

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Kurarinol
Price: ￥4418.0/5mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Kurarinol
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Kurarinol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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