211867-47-9

211867-47-9 structure

Name: Flumorph
Chemical Name: flumorph
CAS Number: 211867-47-9
Molecular Formula: C₂₁H₂₂FNO₄
Molecular Weight: 371.40200
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2018-02-24 08:00:00
Modify Date: 2024-01-02 21:30:26
Flumorph(SYP-L190) is a carboxylic acid amide (CAA) fungicide.IC50 value:Target: Fungicide agentFlumorph did not inhibit the synthesis of cell wall materials, but disturbed the polar deposition of newly synthesized cell wall materials during cystospore germination and hyphal growth. In flumorph-treated hyphae, the most characteristic change was the development of periodic swelling ("beaded" morphology) and the disruption of tip growth. Upon removing flumorph, normal tip growth and organized F-actin were observed again [1]. Flumorph had induced systemic genotoxicity in mammals as it caused DNA damage in all tested vital organs, especially in brain and spleen [2].

Name	flumorph
Synonyms	X5977 (EZ)-4-[3-(3,4-Dimethoxyphenyl)-3-(4-fluorophenyl)acryloyl]morpholine Flumorph [ISO] 4-[3-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-1-oxo-2-propen-1-yl]morpholine (E)-3-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-1-morpholin-4-ylprop-2-en-1-one (2Ξ)-3-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-1-(morpholin-4-yl)prop-2-en-1-one [50% (E)-isomer, 50% (Z)-isomer] (EZ)-3-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-1-morpholinopropenone [50% (E)-isomer, 50% (Z)-isomer] 3-(3,4-Dimethoxyphenyl)-3-(4-fluorophenyl)-1-morpholinoprop-2-en-1-one Flumorph 4-(3-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-1-oxo-2-propenyl)morpholine (EZ)-4-[3-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)acryloyl]morpholine

Description	Flumorph(SYP-L190) is a carboxylic acid amide (CAA) fungicide.IC50 value:Target: Fungicide agentFlumorph did not inhibit the synthesis of cell wall materials, but disturbed the polar deposition of newly synthesized cell wall materials during cystospore germination and hyphal growth. In flumorph-treated hyphae, the most characteristic change was the development of periodic swelling ("beaded" morphology) and the disruption of tip growth. Upon removing flumorph, normal tip growth and organized F-actin were observed again [1]. Flumorph had induced systemic genotoxicity in mammals as it caused DNA damage in all tested vital organs, especially in brain and spleen [2].
Related Catalog	Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Others
References	[1]. Sheng Zhu S, et al. Flumorph Is a Novel Fungicide That Disrupts Microfilament Organization in Phytophthora melonis. Phytopathology. 2007 May;97(5):643-9. [2]. Zhang T, et al. Assessment of genotoxic effects of flumorph by the comet assay in mice organs. Hum Exp Toxicol. 2014 Mar;33(3):224-9.

Hazard Codes	Xn
RIDADR	NONH for all modes of transport