77-41-8

77-41-8 structure

Name: methsuximide
Chemical Name: 1,3-dimethyl-3-phenylpyrrolidine-2,5-dione
CAS Number: 77-41-8
Molecular Formula: C₁₂H₁₃NO₂
Molecular Weight: 203.23700
Catalog: API Nervous system medication Antiepileptic and anticonvulsant
Create Date: 2018-05-14 08:00:00
Modify Date: 2024-01-05 10:37:46
Methsuximide is an anticonvulsant agent. Methsuximide is effective in petit mal, psychomotor and focal motor attacks[1].

Name	1,3-dimethyl-3-phenylpyrrolidine-2,5-dione
Synonyms	Celontin 1,3-Dimethyl-3-phenyl-pyrrolidin-2,5-dion 1,3-dimethyl-3-phenyl-pyrrolidine-2,5-dione mesuximid Mesuximide Mesuximida Metsuccimide Petinutin methsuximide Methsuximid Mesuximidum

Description	Methsuximide is an anticonvulsant agent. Methsuximide is effective in petit mal, psychomotor and focal motor attacks[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. MARY LOUISE SCHOLL, et al. Celontin - a New Anticonvulsant.

Density	1.59g/cm3
Boiling Point	489.2ºC at 760 mmHg
Melting Point	52-53°
Molecular Formula	C₁₂H₁₃NO₂
Molecular Weight	203.23700
Flash Point	191.7ºC
Exact Mass	203.09500
PSA	37.38000
LogP	1.27090
Index of Refraction	1.692
Storage condition	Refrigerator

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WN2625000

CHEMICAL NAME :: Succinimide, N,2-dimethyl-2-phenyl-

CAS REGISTRY NUMBER :: 77-41-8

BEILSTEIN REFERENCE NO. :: 0168315

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C12-H13-N-O2

MOLECULAR WEIGHT :: 203.26

WISWESSER LINE NOTATION :: T5VNVTJ B1 D1 DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 6,740,1954 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 1006 mg/kg

SEX/DURATION :: female 8-10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

REFERENCE :: FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 38,438,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6158 No. of Facilities: 29 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 876 (estimated) No. of Female Employees: 408 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H412
Precautionary Statements	P301 + P312 + P330
RIDADR	NONH for all modes of transport

14231-67-5

74-89-5

77-41-8

Literature: Vystrcil; Cerny Collection of Czechoslovak Chemical Communications, 1959 , vol. 24, p. 804,807 Show Details Miller; Long Journal of the American Chemical Society, 1951 , vol. 73, p. 4895,4897

Precursor 2
14231-67-5 74-89-5
DownStream 1
39122-23-1