191338-86-0

191338-86-0 structure

Name: caspase-8 inhibitor
Chemical Name: ac-ietd-cho
CAS Number: 191338-86-0
Molecular Formula: C₂₁H₃₄N₄O₁₀
Molecular Weight: 502.516
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-11-28 21:12:04
Modify Date: 2025-08-22 22:05:53
Ac-?IETD-?CHO is a potent, reversible inhibitor of granzyme B and caspase-8. Ac-?IETD-?CHO inhibits Fas-mediated apoptotic cell death, hemorrhage, and liver failure. Ac-?IETD-?CHO also inhibits cytotoxic T lymphocytes induced cell death[1][2].

Name	ac-ietd-cho
Synonyms	ac-ietd-aldehyde L-Threoninamide, N-acetyl-L-isoleucyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]- granzyme b inhibitor (aldehyde) ac-ile-glu-thr-asp-cho N-Acetyl-L-isoleucyl-L-α-glutamyl-N-[(2S)-1-carboxy-3-oxo-2-propanyl]-L-threoninamide ietd-cho,cell-permeable ac-ile-glu-thr-asp-h (aldehyde) granzyme b inhibitor ii pase-8 inhibitor i ac-ile-glu-thr-asp-aldehyde pase 8 inhibitor 1

Description	Ac-?IETD-?CHO is a potent, reversible inhibitor of granzyme B and caspase-8. Ac-?IETD-?CHO inhibits Fas-mediated apoptotic cell death, hemorrhage, and liver failure. Ac-?IETD-?CHO also inhibits cytotoxic T lymphocytes induced cell death[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. Bajt ML, et al. Protection against Fas receptor-mediated apoptosis in hepatocytes and nonparenchymal cells by a caspase-8 inhibitor in vivo: evidence for a postmitochondrial processing of caspase-8. Toxicol Sci. 2000 Nov;58(1):109-17. [2]. Hayashida M, et al. Cell death induction by CTL: perforin/granzyme B system dominantly acts for cell death induction in human hepatocellular carcinoma cells. Proc Soc Exp Biol Med. 2000 Nov;225(2):143-50.

WGK Germany	3