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191338-86-0

191338-86-0 structure
191338-86-0 structure
  • Name: caspase-8 inhibitor
  • Chemical Name: ac-ietd-cho
  • CAS Number: 191338-86-0
  • Molecular Formula: C21H34N4O10
  • Molecular Weight: 502.516
  • Catalog: Signaling Pathways Apoptosis Apoptosis
  • Create Date: 2018-11-28 21:12:04
  • Modify Date: 2024-01-02 10:37:21
  • Ac-?IETD-?CHO is a potent, reversible inhibitor of granzyme B and caspase-8. Ac-?IETD-?CHO inhibits Fas-mediated apoptotic cell death, hemorrhage, and liver failure. Ac-?IETD-?CHO also inhibits cytotoxic T lymphocytes induced cell death[1][2].

Name ac-ietd-cho
Synonyms ac-ietd-aldehyde
L-Threoninamide, N-acetyl-L-isoleucyl-L-α-glutamyl-N-[(1S)-2-carboxy-1-formylethyl]-
granzyme b inhibitor (aldehyde)
ac-ile-glu-thr-asp-cho
N-Acetyl-L-isoleucyl-L-α-glutamyl-N-[(2S)-1-carboxy-3-oxo-2-propanyl]-L-threoninamide
ietd-cho,cell-permeable
ac-ile-glu-thr-asp-h (aldehyde)
granzyme b inhibitor ii
pase-8 inhibitor i
ac-ile-glu-thr-asp-aldehyde
pase 8 inhibitor 1
Density 1.3±0.1 g/cm3
Boiling Point 971.9±65.0 °C at 760 mmHg
Molecular Formula C21H34N4O10
Molecular Weight 502.516
Flash Point 541.6±34.3 °C
Exact Mass 502.227478
PSA 228.30000
LogP -0.55
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.527
WGK Germany 3