112727-80-7
112727-80-7 structure
- Name: Renzapride
- Chemical Name: 4-amino-N-(1-azabicyclo[3.3.1]nonan-4-yl)-5-chloro-2-methoxybenzamide
- CAS Number: 112727-80-7
- Molecular Formula: C16H22ClN3O2
- Molecular Weight: 323.81800
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2018-04-20 08:00:00
- Modify Date: 2025-09-02 23:57:25
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Renzapride (BRL 24924), a substituted benzamide, is a full 5-HT4 receptor agonist with a Ki value of 115 nM. Renzapride (BRL 24924) is also a 5HT2b and 5HT3 receptor antagonist[1]. Renzapride could be used for constipation predominant irritable bowel syndrome (C-IBS) study[2].
| Name | 4-amino-N-(1-azabicyclo[3.3.1]nonan-4-yl)-5-chloro-2-methoxybenzamide |
|---|---|
| Synonyms |
MK-0646
Renzaprida Renzapride Renzapridum |
| Description | Renzapride (BRL 24924), a substituted benzamide, is a full 5-HT4 receptor agonist with a Ki value of 115 nM. Renzapride (BRL 24924) is also a 5HT2b and 5HT3 receptor antagonist[1]. Renzapride could be used for constipation predominant irritable bowel syndrome (C-IBS) study[2]. |
|---|---|
| Related Catalog | |
| Target |
5-HT4 Receptor:115 nM (Ki) |
| In Vitro | Renzapride replaces specific binding of [H3] GR 113808 (a selective 5-HT receptor antagonist) to cloned human 5-HT4 receptors with a Ki value of 115 nM[3]. |
| In Vivo | Renzapride (BRL 24924) (100 µg i.v.) results in a partial reverse of both the delayed solid and liquid meals emptying[2]. Renzapride (BRL 24924) (0.5-1 mg/kg) significantly increases the rate of emptying of a 51Cr-labeled liquid meal from the murine stomach[4]. Animal Model: Dog (simulating gastroparesis)[2] Dosage: 100 µg/kg Administration: i.v. Result: Results in a partial reverse of both the delayed solid and liquid meals emptying. Animal Model: Mice (30-45g)[2] Dosage: 0.5-1 mg/kg Administration: p.o. Result: Significantly increase the rate of emptying of a 51Cr-labeled liquid meal from the murine stomach. |
| References |
| Density | 1.3g/cm3 |
|---|---|
| Boiling Point | 469.2ºC at 760mmHg |
| Molecular Formula | C16H22ClN3O2 |
| Molecular Weight | 323.81800 |
| Flash Point | 237.6ºC |
| Exact Mass | 323.14000 |
| PSA | 67.59000 |
| LogP | 3.05490 |
| Vapour Pressure | 5.6E-09mmHg at 25°C |
| Index of Refraction | 1.614 |