83647-97-6

83647-97-6 structure

Name: Spirapril
Chemical Name: (8S)-7-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid
CAS Number: 83647-97-6
Molecular Formula: C₂₂H₃₀N₂O₅S₂
Molecular Weight: 466.61400
Catalog: API Circulatory system medication Antihypertensive drug
Create Date: 2018-04-03 08:00:00
Modify Date: 2026-06-30 15:42:38
Spirapril is a potent and cross the blood-brain barrier angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril competitively binds to ACE and prevents the conversion of angiotensin I to angiotensin II. Spirapril is an orally active prodrug of Spiraprilat and can be used for the research of hypertension, congestive heart failure[1][2][3].

Name	(8S)-7-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid
Synonyms	Sandopfil SPIRAPRIL FOR SYSTEM SUITABILITY Y(CRM STANDD) Setrilan Spiraprilum Spiraprilum [Latin] Espirapril Sandopril 1,4-Dithia-7-azaspiro(4,4)nonane-8-cboxylic acid, 7-(2-((1-(ethoxycbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-, (8S-(7(R(R)),8R)) Spirapril [inn:ban] SPIRAPRIL FOR SYSTEM SUITABILITY Y Spiraprilum [latin] Spirapril (INN) Espirapril [spanish] Spirapril //BP Espirapril [Spanish] Spiraprilic acid (8S-(7(R(R)),8R))-7-(2-((1-(Ethoxycbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-1,4-dithia-7-azaspirononane-8-cboxylic acid 1,4-Dithia-7-azaspirononane-8-cboxylic acid, 7-[(2S)-2-[[(1S)-1-(ethoxycbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-, (8S) Spirapril [INN:BAN] Renormax SPIRAPRIL Not established Sch-33844 Brn

Description	Spirapril is a potent and cross the blood-brain barrier angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril competitively binds to ACE and prevents the conversion of angiotensin I to angiotensin II. Spirapril is an orally active prodrug of Spiraprilat and can be used for the research of hypertension, congestive heart failure[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)
In Vivo	Spirapril (feeding needle; 10 mg/kg; 3 weeks) decreases alcohol intake in TGM123 mice and dose not reduce the alcohol consumption in TLM mice[2]. Spirapril shows a 40.2% reduction in ACE activity in brain membrane from treated-mice[2]. Spirapril can crosses the blood-brain barrier and suppresses the transgene effect in the experiments[2]. Spirapril prevents left ventricular hypertrophy, decreases myocardial damage and promotes angiogenesis in spontaneously hypertensive rats[3].
References	[1]. Noble S, Sorkin EM. Spirapril. A preliminary review of its pharmacology and therapeutic efficacy in the treatment of hypertension. Drugs. 1995 May;49(5):750-66. [2]. Maul B, et al. Alcohol consumption is controlled by angiotensin II. FASEB J. 2001 Jul;15(9):1640-2. [3]. Olivetti G, et al. Spirapril prevents left ventricular hypertrophy, decreases myocardial damage and promotes angiogenesis in spontaneously hypertensive rats. J Cardiovasc Pharmacol. 1993 Mar;21(3):362-70.

Density	1.32 g/cm3
Boiling Point	697.8ºC at 760 mmHg
Molecular Formula	C₂₂H₃₀N₂O₅S₂
Molecular Weight	466.61400
Flash Point	375.8ºC
Exact Mass	466.16000
PSA	146.54000
LogP	2.71960
Index of Refraction	1.621
Storage condition	-20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JO4925000

CHEMICAL NAME :: 1,4-Dithia-7-azaspiro(4,4)nonane-8-carboxylic acid, 7-(2-((1-(ethoxycarbonyl)-3-phenylpropyl) amino)-1-oxopropyl)-, (8S-(7(R*(R*)),8R*))-

CAS REGISTRY NUMBER :: 83647-97-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C22-H30-N2-O5-S2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 5,98,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 5,98,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 5,98,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 5,98,1985 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13500 mg/kg/90D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 5,98,1985

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 5400 mg/kg/90D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 5,98,1985

Precursor 8
82717-96-2 83507-89-5 83507-90-8 64187-47-9
503322-63-2 83623-66-9 113949-44-3 83552-44-7
DownStream 1
94841-17-5

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