ZM 306416

Modify Date: 2024-01-09 17:21:07

ZM 306416 structure	Common Name	ZM 306416
	CAS Number	690206-97-4	Molecular Weight	333.745
	Density	1.4±0.1 g/cm3	Boiling Point	434.1±45.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₁₃ClFN₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	216.4±28.7 °C

Use of ZM 306416

ZM-306416 (CB 676475) is a potent inhibitor of VEGFR with IC50s of 0.1 and 2 μM for KDR and Flt, respectively. ZM-306416 is also a EGFR inhibitor with an IC50 of <10 nM.

Name	N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine
Synonym	More Synonyms

Description	ZM-306416 (CB 676475) is a potent inhibitor of VEGFR with IC50s of 0.1 and 2 μM for KDR and Flt, respectively. ZM-306416 is also a EGFR inhibitor with an IC50 of <10 nM.
Related Catalog	Research Areas >> Cancer
Target	KDR:100 nM (IC50) Flt-1:2 μM (IC50)
In Vitro	ZM-306416 selective anti-proliferative effect toward the EGFR addicted NSCLC cell lines H3255 and HCC4011 (IC50=0.09±0.007 μM and 0.072±0.001 μM respectively), while sparing the wild type EGFR cell lines A549 and H2030 (IC50>10 μM). ZM-306416 is also found to inhibit the ABL in vitro kinase activity with a less potent IC50 value of 1.3±0.2 μM toward the ABL kinase[2].
References	[1]. Han SY, Park SS, Lee WG, Synthesis of a novel biotin-tagged photoaffinity probe for VEGF receptor tyrosine kinases. Bioorg Med Chem Lett. 2006 Jan 1;16(1):129-33. [2]. Antczak C, Mahida JP, Bhinder B, A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: implications in drug discovery. J Biomol Screen. 2012 Aug;17(7):885-99.

Density	1.4±0.1 g/cm3
Boiling Point	434.1±45.0 °C at 760 mmHg
Molecular Formula	C₁₆H₁₃ClFN₃O₂
Molecular Weight	333.745
Flash Point	216.4±28.7 °C
Exact Mass	333.068024
PSA	56.27000
LogP	4.15
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.653
Storage condition	Desiccate at RT

4-Quinazolinamine, N-(4-chloro-2-fluorophenyl)-6,7-dimethoxy-

N-(4-Chloro-2-fluorophenyl)-6,7-dimethoxy-4-quinazolinamine

N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine

Anilinoquinazoline deriv. 4

ZM-306416

ZM306416

ZM 306416

DC Chemicals Limited
China
Product Name: ZM306416
Price: $400.0/100mg $750.0/250mg $1500.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride (ZM 306416)
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: $147/10mM*1mLinDMSO

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ZM 306416

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