114012-12-3
114012-12-3 structure
- Name: PHACLOFEN
- Chemical Name: Phaclofen,(RS)-3-Amino-2-(4-chlorophenyl)propylphosphonicacid
- CAS Number: 114012-12-3
- Molecular Formula: C9H13ClNO3P
- Molecular Weight: 249.63100
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
- Create Date: 2018-06-08 16:07:53
- Modify Date: 2025-08-21 20:58:27
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Phaclofen is a selective GABAB receptor antagonist. Phaclofen is a peripheral and central baclofen antagonist. Phaclofen maybe a potential compound in determining the physiological significance of central and peripheral bicuculline-insensitive receptors with which GABA and (-)-baclofen interact[1][2].
| Name | Phaclofen,(RS)-3-Amino-2-(4-chlorophenyl)propylphosphonicacid |
|---|---|
| Synonyms |
3-Amino-2-(4-chlorophenyl)propanephosphonic acid
MFCD00069328 |
| Description | Phaclofen is a selective GABAB receptor antagonist. Phaclofen is a peripheral and central baclofen antagonist. Phaclofen maybe a potential compound in determining the physiological significance of central and peripheral bicuculline-insensitive receptors with which GABA and (-)-baclofen interact[1][2]. |
|---|---|
| Related Catalog | |
| Target |
GABAB receptor[1] |
| In Vivo | Phaclofen (100 nmol; intrathecal injection) antagonizes the depressant effect of baclofen. Phaclofen (100 nmol) is devoid of stimulatory or depressant effects on spinal reflexes[3]. |
| References |
| Density | 1.432 g/cm3 |
|---|---|
| Boiling Point | 467.1ºC at 760 mmHg |
| Molecular Formula | C9H13ClNO3P |
| Molecular Weight | 249.63100 |
| Flash Point | 236.3ºC |
| Exact Mass | 249.03200 |
| PSA | 93.36000 |
| LogP | 2.26030 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
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114012-12-3 |
| Literature: Hall Synthesis, 1989 , # 6 p. 442 - 443 |
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114012-12-3 |
| Literature: Hall Synthesis, 1989 , # 6 p. 442 - 443 |
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114012-12-3 |
| Literature: Chiefari, John; Galanopoulos, Speros; Janowski, Wit K.; Kerr, David I. B.; Prager, Rolf H. Australian Journal of Chemistry, 1987 , vol. 40, # 9 p. 1511 - 1518 |
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114012-12-3 |
| Literature: Chiefari, John; Galanopoulos, Speros; Janowski, Wit K.; Kerr, David I. B.; Prager, Rolf H. Australian Journal of Chemistry, 1987 , vol. 40, # 9 p. 1511 - 1518 |
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114012-12-3 |
| Literature: Chiefari, John; Galanopoulos, Speros; Janowski, Wit K.; Kerr, David I. B.; Prager, Rolf H. Australian Journal of Chemistry, 1987 , vol. 40, # 9 p. 1511 - 1518 |
| Precursor 3 | |
|---|---|
| DownStream 0 | |