DC Chemicals Limited
China
Product Name: AC-55649
Price: $900.0/100mg $1800.0/250mg $3600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

59662-49-6

59662-49-6 structure

59662-49-6 structure

Name: AC 55649
Chemical Name: 4-(4-octylphenyl)benzoic acid
CAS Number: 59662-49-6
Molecular Formula: C₂₁H₂₆O₂
Molecular Weight: 310.43000
Catalog: Signaling Pathways Metabolic Enzyme/Protease RAR/RXR
Create Date: 2018-08-09 15:27:32
Modify Date: 2024-01-09 12:03:11
AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9.

Name	4-(4-octylphenyl)benzoic acid
Synonyms	MFCD00157040 4-Octyl-4'-biphenylcarboxylic acid 8BCA 4-n-octylbiphenyl-4'-carboxylic acid 4'-Octylbiphenyl-4-carboxylic acid octyldiphenylcarboxylic acid 4'-octyl-4-phenylbenzoic acid 4'-octyloxy-4-biphenylcarboxylic acid

Description	AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR Research Areas >> Others
Target	RARβ2:6.9 (pEC50)
In Vitro	AC-55649 is a potent, highly isoform-selective agonist at the human RARβ2 receptor, with a pEC50 of 6.9[1]. AC-55649 is a potent and selective activator of RARβ2 transcriptional activity[2].
References	[1]. Lund BW, et al. Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist. J Med Chem. 2005 Dec 1;48(24):7517-9. [2]. Piu F, et al. Identification of novel subtype selective RAR agonists. Biochem Pharmacol. 2005 Dec 19;71(1-2):156-62.

Density	1.037g/cm3
Boiling Point	462ºC at 760 mmHg
Molecular Formula	C₂₁H₂₆O₂
Molecular Weight	310.43000
Flash Point	216.9ºC
Exact Mass	310.19300
PSA	37.30000
LogP	5.95480
Index of Refraction	1.548
Storage condition	2-8℃

Hazard Statements	H413
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
HS Code	2916399090

52709-84-9 structure

52709-84-9

~93%

59662-49-6 structure

59662-49-6

Literature: Pedersen, Palle J.; Adolph, Sidsel K.; Subramanian, Arun K.; Arouri, Ahmad; Andresen, Thomas L.; Mouritsen, Ole G.; Madsen, Robert; Madsen, Mogens W.; Peters, Guenther H.; Clausen, Mads H. Journal of Medicinal Chemistry, 2010 , vol. 53, # 9 p. 3782 - 3792

Precursor 1
52709-84-9
DownStream 0

HS Code	2916399090
Summary	2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%