Name | 3-[[(2R)-2-hydroxypropyl]amino]-3-methyl-N-[(3R)-2-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4,5-dihydro-3H-1-benzazepin-3-yl]butanamide |
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Synonyms |
hms3268f14
l-692,585 |
Description | L-692585 is a potent and nonpeptidyl growth hormone secretagogue receptor (GHS-R1a) agonist, with a Ki of 0.8 nM. L-692585 acts directly on somatotropes causing GH release[1][2]. |
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Related Catalog | |
Target |
Ki: 0.8 nM (GHS-R1a)[1] |
In Vitro | L-692585 (10 µM; 2 min) produces a prompt transient increase in [Ca2+]i, following by the sustained decline to a plateau above the basal level in GH cells[2]. L-692585 (0.01-10 µM; 2 min) induces release of growth hormone (GH) in a dose-dependent manner from isolated porcine somatotropes[2]. L-692585 (100 nM) significantly increases the number and size of plaques, and it also causes a significant increase in total secretion index (TSI) [2]. |
In Vivo | L-692585 (0.01-0.1 mg/kg; i.v. once daily for 2 weeks) increases peak plasma GH levels and total GH release[3]. L-692585 (0.005-0.1 mg/kg; a single i.v.) significantly increases peak GH concentrations 4.3-fold at a dose of 0.005 mg/kg, 7-fold at a dose of 0.02 mg/kg, and 21-fold at a dose of 0.10 mg/kg in vivo[3]. Animal Model: Beagles (1-1.5 years old ; weighting 8.5-16.0 kg)[3] Dosage: 0.01, 0.1 mg/kg Administration: I.v. once daily for 2 weeks Result: Increased the peak plasma GH levels and total GH release on days 1, 8 and 15 in a dose-dependent manner, and no desensitization was evident. |
References |
Density | 1.31g/cm3 |
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Molecular Formula | C32H37N7O3 |
Molecular Weight | 567.68100 |
Exact Mass | 567.29600 |
PSA | 136.13000 |
LogP | 4.48380 |
Index of Refraction | 1.66 |