DC Chemicals Limited
China
Product Name: Rp-cAMPS
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

73208-40-9

73208-40-9 structure

Name: Rp-cAMPS
Chemical Name: cAMPS-Rp, triethylammonium salt,(R)-Adenosine,cyclic3',5'-(hydrogenphosphorothioate)triethylammonium
CAS Number: 73208-40-9
Molecular Formula: C₁₆H₂₇N₆O₅PS
Molecular Weight: 446.46200
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK PKA
Create Date: 2018-02-17 08:00:00
Modify Date: 2024-01-05 18:31:44
Rp-cAMPS, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 µM and 4.5 µM, respectively) antagonist. Rp-cAMPS is resistant to hydrolysis by phosphodiesterases[1][2][3][4][5][6].

Name	cAMPS-Rp, triethylammonium salt,(R)-Adenosine,cyclic3',5'-(hydrogenphosphorothioate)triethylammonium
Synonyms	sp-camps triethyl ammonium salt rp-adenosine 3',5'-cyclic monophosphothioate triethylamine MFCD03703495 sp-adenosine 3',5'-cyclic monophosphothioate triethylamine sp-camps triethylamine sp-camps tea camps-sp,triethylammonium salt camps tea,sp-isomer rp-camps triethylamine

Description	Rp-cAMPS, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 µM and 4.5 µM, respectively) antagonist. Rp-cAMPS is resistant to hydrolysis by phosphodiesterases[1][2][3][4][5][6].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Signaling Pathways >> Stem Cell/Wnt >> PKA Research Areas >> Neurological Disease
Target	Ki: 6.05 µM (PKA I) and 9.75 µM (PKA II)[1]
In Vitro	A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission[2].
In Vivo	Rp-cAMPS (10 μM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons[2].
References	[1]. R J de Wit, et al. Inhibitory action of certain cyclophosphate derivatives of cAMP on cAMP-dependent protein kinases. Eur J Biochem. 1984 Jul 16;142(2):255-60. [2]. Rothermel JD, et al. A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3',5'-(cyclic)phosphorothioate with purified cyclic AMP-dependent protein kinase. Biochem J. 1988 May 1;251(3):757-62. [3]. Fu Y, et al. PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior. Mol Pain. 2008 Jul 16;4:26. [4]. Kuriyama S, et al. Isoproterenol inhibits rod outer segment phagocytosis by both cAMP-dependent and independent pathways. Invest Ophthalmol Vis Sci. 1995 Mar;36(3):730-6. [5]. Dostmann WR, et al. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J Biol Chem. 1990 Jun 25;265(18):10484-91. [6]. Van Haastert PJ, et al. Competitive cAMP antagonists for cAMP-receptor proteins. J Biol Chem. 1984 Aug 25;259(16):10020-4.

Molecular Formula	C₁₆H₂₇N₆O₅PS
Molecular Weight	446.46200
Exact Mass	446.15000
PSA	186.46000
LogP	2.04940

Safety Phrases	S22-S24/25

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