Name | cct-018159 |
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Synonyms |
4-[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-METHYL-1H-PYRAZOL-5-YL]-6-ETHYLBENZENE-1,3-DIOL
4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethyl-1,3-benzenediol 4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethylbenzene-1,3-diol CCT-018159 CCT 018159,4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethyl-1,3-benzenediol 1,3-Benzenediol, 4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethyl- |
Description | CCT018159, a 3,4-diaryl pyrazoleresorcinol, is a ATP-competitive HSP90 ATPase activity inhibitor with IC50s of 3.2 and 6.6 µM for human Hsp90β and yeast Hsp90, respectively. CCT018159 caused cell cytostasis associated with a G1 arrest and induces apoptosis. CCT018159 inhibits key endothelial and tumor cell functions implicated in invasion and angiogenesis[1]. |
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Related Catalog | |
Target |
human Hsp90β:3.2 μM (IC50) yeast Hsp90:6.6 μM (IC50) |
References |
Density | 1.3±0.1 g/cm3 |
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Boiling Point | 547.3±50.0 °C at 760 mmHg |
Molecular Formula | C20H20N2O4 |
Molecular Weight | 352.384 |
Flash Point | 284.8±30.1 °C |
Exact Mass | 352.142303 |
PSA | 87.60000 |
LogP | 2.79 |
Vapour Pressure | 0.0±1.5 mmHg at 25°C |
Index of Refraction | 1.647 |