130717-51-0

130717-51-0 structure

Name: FR 122047 hydrochloride
Chemical Name: FR 122047 hydrochloride,1-[[4,5-bis(4-Methoxyphenyl)-2-thiazolyl]carbonyl]-4-methylpiperazinehydrochloride
CAS Number: 130717-51-0
Molecular Formula: C₂₃H₂₆ClN₃O₃S
Molecular Weight: 459.98900
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2018-12-27 15:09:18
Modify Date: 2024-04-02 14:34:28
FR122047 (hydrochloride) is a selective and oral active inhibitor of COX-1 with an IC50 of 28 nM. FR122047 hydrochloride has antiplatelet, analgesic and anti-inflammatory effects in vivo[1][2][3].

Name	FR 122047 hydrochloride,1-[[4,5-bis(4-Methoxyphenyl)-2-thiazolyl]carbonyl]-4-methylpiperazinehydrochloride

Description	FR122047 (hydrochloride) is a selective and oral active inhibitor of COX-1 with an IC50 of 28 nM. FR122047 hydrochloride has antiplatelet, analgesic and anti-inflammatory effects in vivo[1][2][3].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-1:28 nM (IC50)
References	[1]. Dohi M, et al. The anti-platelet actions of FR122047, a novel cyclooxygenase inhibitor. Eur J Pharmacol. 1993 Oct 19;243(2):179-84. [2]. Ochi T, Motoyama Y, Goto T. The analgesic effect profile of FR122047, a selective cyclooxygenase-1 inhibitor, in chemical nociceptive models. Eur J Pharmacol. 2000 Mar 10;391(1-2):49-54. [3]. Ochi T, Goto T. Differential effect of FR122047, a selective cyclo-oxygenase-1 inhibitor, in rat chronic models of arthritis. Br J Pharmacol. 2002 Feb;135(3):782-8.