FR 122047 hydrochloride

Modify Date: 2024-04-02 14:34:28

FR 122047 hydrochloride structure	Common Name	FR 122047 hydrochloride
	CAS Number	130717-51-0	Molecular Weight	459.98900
	Density	N/A	Boiling Point	562.7ºC at 760 mmHg
	Molecular Formula	C₂₃H₂₆ClN₃O₃S	Melting Point	N/A
	MSDS	USA	Flash Point	294.1ºC

Use of FR 122047 hydrochloride

FR122047 (hydrochloride) is a selective and oral active inhibitor of COX-1 with an IC50 of 28 nM. FR122047 hydrochloride has antiplatelet, analgesic and anti-inflammatory effects in vivo[1][2][3].

Name	FR 122047 hydrochloride,1-[[4,5-bis(4-Methoxyphenyl)-2-thiazolyl]carbonyl]-4-methylpiperazinehydrochloride

Description	FR122047 (hydrochloride) is a selective and oral active inhibitor of COX-1 with an IC50 of 28 nM. FR122047 hydrochloride has antiplatelet, analgesic and anti-inflammatory effects in vivo[1][2][3].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-1:28 nM (IC50)
References	[1]. Dohi M, et al. The anti-platelet actions of FR122047, a novel cyclooxygenase inhibitor. Eur J Pharmacol. 1993 Oct 19;243(2):179-84. [2]. Ochi T, Motoyama Y, Goto T. The analgesic effect profile of FR122047, a selective cyclooxygenase-1 inhibitor, in chemical nociceptive models. Eur J Pharmacol. 2000 Mar 10;391(1-2):49-54. [3]. Ochi T, Goto T. Differential effect of FR122047, a selective cyclo-oxygenase-1 inhibitor, in rat chronic models of arthritis. Br J Pharmacol. 2002 Feb;135(3):782-8.

Boiling Point	562.7ºC at 760 mmHg
Molecular Formula	C₂₃H₂₆ClN₃O₃S
Molecular Weight	459.98900
Flash Point	294.1ºC
Exact Mass	459.13800
PSA	83.14000
LogP	4.55970
Vapour Pressure	1.1E-12mmHg at 25°C

DC Chemicals Limited
China
Product Name: FR-122047
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-[[4,5-BIS(4-METHOXYPHENYL)-2-THIAZOLYL]CARBONYL]-4-METHYLPIPERAZINE HYDROCHLORIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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