194874-06-1
194874-06-1 structure
- Name: Apoptolidin
- Chemical Name: apoptolidin A
- CAS Number: 194874-06-1
- Molecular Formula: C58H96O21
- Molecular Weight: 1129.37000
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2017-01-26 15:14:27
- Modify Date: 2026-07-18 10:53:04
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Apoptolidin is a polyketide isolated from Nocardiopsis bacteria[1]. Apoptolidin is a selective mitochondrial F1FO ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC50=10-17 ng/ml) but not in normal cells[1][2].
| Name | apoptolidin A |
|---|---|
| Synonyms |
FU 40A
2-Amino-1-hydroxy-7-methoxynitosene Apo-mitomycin A Apoptolidin A Ready Made Apoptolidin A Ready Made Solution L-glycero-α-D-galacto-2-Nonulopyranose, O-2,6-dideoxy-3-O-methyl-β-D-abino-hexopyranosyl-(1→4)-O-2,6-dideoxy-3-C-methyl-α-L-abino-hexopyranosyl-(1→8)-3,5,7-trideoxy-1-C-[(2S,4S,5S,8E,10E,12R,13R,14E,16E,18E)-12-[(6-deoxy-4-O-methyl-α-L-glucopyranosyl)oxy]-5-hydroxy-4-methoxy-9,13,15,17,19-pentam |
| Description | Apoptolidin is a polyketide isolated from Nocardiopsis bacteria[1]. Apoptolidin is a selective mitochondrial F1FO ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC50=10-17 ng/ml) but not in normal cells[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Apoptolidin has cytotoxicity against normal and transformed cells, it against RG-E1A-7,RG-E1A19K-2, RG-E1A54K-9, RG-E1-4 and Adl2-3Y1 with IC50 values of 11 ng/ml,10 ng/ml,13 ng/ml, 10 ng/ml and 17 ng/ml, respectively[1]. |
| References |
| Molecular Formula | C58H96O21 |
|---|---|
| Molecular Weight | 1129.37000 |
| Exact Mass | 1128.64000 |
| PSA | 289.67000 |
| LogP | 3.58730 |
| RIDADR | NA 1993 / PGIII |
|---|---|
| Flash Point(F) | 188.6 °F |
| Flash Point(C) | 87 °C |
| Precursor 1 | |
|---|---|
| DownStream 1 | |