194874-06-1

194874-06-1 structure

Name: Apoptolidin
Chemical Name: apoptolidin A
CAS Number: 194874-06-1
Molecular Formula: C₅₈H₉₆O₂₁
Molecular Weight: 1129.37000
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-01-26 15:14:27
Modify Date: 2024-01-17 20:42:43
Apoptolidin is a polyketide isolated from Nocardiopsis bacteria[1]. Apoptolidin is a selective mitochondrial F1FO ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC50=10-17 ng/ml) but not in normal cells[1][2].

Name	apoptolidin A
Synonyms	Apoptolidin A Ready Made 2-Amino-1-hydroxy-7-methoxynitosene Apo-mitomycin A

Description	Apoptolidin is a polyketide isolated from Nocardiopsis bacteria[1]. Apoptolidin is a selective mitochondrial F1FO ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC50=10-17 ng/ml) but not in normal cells[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Membrane Transporter/Ion Channel >> ATP Synthase
In Vitro	Apoptolidin has cytotoxicity against normal and transformed cells, it against RG-E1A-7,RG-E1A19K-2, RG-E1A54K-9, RG-E1-4 and Adl2-3Y1 with IC50 values of 11 ng/ml,10 ng/ml,13 ng/ml, 10 ng/ml and 17 ng/ml, respectively[1].
References	[1]. J W Kim, et al. Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp. J Antibiot (Tokyo). 1997 Jul;50(7):628-30. [2]. A R Salomon, et al. Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase. Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14766-71.

502156-06-1

194874-06-1

476647-30-0

194874-06-1

Literature: Wender, Paul A; Gulledge, Aaron V; Jankowski, Orion D; Seto, Haruo Organic letters, 2002 , vol. 4, # 22 p. 3819 - 3822