Apoptolidin
Modify Date: 2025-08-25 11:44:09
Apoptolidin structure
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Common Name | Apoptolidin | ||
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| CAS Number | 194874-06-1 | Molecular Weight | 1129.37000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C58H96O21 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 188.6 °F | |
Use of ApoptolidinApoptolidin is a polyketide isolated from Nocardiopsis bacteria[1]. Apoptolidin is a selective mitochondrial F1FO ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC50=10-17 ng/ml) but not in normal cells[1][2]. |
| Name | apoptolidin A |
|---|---|
| Synonym | More Synonyms |
| Description | Apoptolidin is a polyketide isolated from Nocardiopsis bacteria[1]. Apoptolidin is a selective mitochondrial F1FO ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC50=10-17 ng/ml) but not in normal cells[1][2]. |
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| Related Catalog | |
| In Vitro | Apoptolidin has cytotoxicity against normal and transformed cells, it against RG-E1A-7,RG-E1A19K-2, RG-E1A54K-9, RG-E1-4 and Adl2-3Y1 with IC50 values of 11 ng/ml,10 ng/ml,13 ng/ml, 10 ng/ml and 17 ng/ml, respectively[1]. |
| References |
| Molecular Formula | C58H96O21 |
|---|---|
| Molecular Weight | 1129.37000 |
| Exact Mass | 1128.64000 |
| PSA | 289.67000 |
| LogP | 3.58730 |
| RIDADR | NA 1993 / PGIII |
|---|---|
| Flash Point(F) | 188.6 °F |
| Flash Point(C) | 87 °C |
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Apoptolidin CAS#:194874-06-1 |
| Literature: Nicolaou; Li, Yiwei; Fylaktakidou, Konstantina C.; Mitchell, Helen J.; Sugita, Kazuyuki Angewandte Chemie - International Edition, 2001 , vol. 40, # 20 p. 3854 - 3857 |
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Apoptolidin CAS#:194874-06-1 |
| Literature: Wender, Paul A; Gulledge, Aaron V; Jankowski, Orion D; Seto, Haruo Organic letters, 2002 , vol. 4, # 22 p. 3819 - 3822 |
| Precursor 1 | |
|---|---|
| DownStream 1 | |
| Apoptolidin A Ready Made |
| 2-Amino-1-hydroxy-7-methoxynitosene |
| Apo-mitomycin A |