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Henan Tianfu Chemical Co., Ltd.
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500287-72-9

500287-72-9 structure

500287-72-9 structure

Name: Rilpivirine
Chemical Name: rilpivirine
CAS Number: 500287-72-9
Molecular Formula: C₂₂H₁₈N₆
Molecular Weight: 366.418
Catalog: Biochemical Inhibitor Microbiology Reverse Transcriptase inhibitor
Create Date: 2018-04-04 08:00:00
Modify Date: 2026-07-03 11:01:42
Rilpivirine (R278474; TMC278) is a type of anti-HIV medicine called a non-nucleoside reverse transcriptase inhibitor (NNRTI).

Name	rilpivirine
Synonyms	[3H]-Rilpivirine Pivelin 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile Rilpivirine R TMC-278 Seebio Rilpivirine Rilpivirine(R Rilpivirine, >= 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile //BP 4-{[4-({4-[(1E)-2-cyanoeth-1-en-1-yl]-2,6-diMethylphenyl}amino)pyriMidin-2-yl]amino}benzonitrile R 278474; TMC 278; R-278474; R278474; TMC278; TMC-278 (E)-4-(4-(4-(2-cyanovinyl)-2,6-diMethylphenylaMino)pyriMidin-2-ylaMino)benzonitrile pivirine BENZONITRILE。RILPIVIRINE Edurant 4-[4-[4-[(E)-2-Cyanovinyl]-2,6-dimethylphenylamino]pyrimidin D6-Rilpivirine HCl BENZONITRILE,4-((4-((4-((1E)-2-CYANOETHEN YL)-2,6-DIMETHYLPHENYL)AMINO)-2-PYRIMIDINYL)AMINO)-) 4-[[4-[[4-[(E)-2-Cyanovinyl]-2,6-diMethylphenyl]amino]pyriMidin-2-yl]amino]benzonitrile 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile Glycerol Impurity 39 Rilpivirine/TMC-278 Rilpivirine, 10 mM in DMSO Rilpivirine(RPV) Lipavirin/Lipavirin DB08864 4-[[4-[4-[(E)-2-cyanoethenyl]-2,6-dimethylanilino]pyrimidin-2-yl]amino]benzonitrile R 278474 Benzonitrile,4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-diMethylphenyl]amino]-2-pyriMidinyl]amino] 4-{[4-({4-[(E)-2-Cyanovinyl]-2,6-dimethylphenyl}amino)-2-pyrimidinyl]amino}benzonitrile Rilpivirin 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile UNII-FI96A8X663 RilpivirineQ: What is Rilpivirine Q: What is the CAS Number of Rilpivirine Q: What is the storage condition of Rilpivirine Q: What e the applications of Rilpivirine

Description	Rilpivirine (R278474; TMC278) is a type of anti-HIV medicine called a non-nucleoside reverse transcriptase inhibitor (NNRTI).
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Signaling Pathways >> Anti-infection >> Reverse Transcriptase Research Areas >> Infection
Target	NNRTIs
In Vitro	Rilpivirine(TMC278) is a next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI), active against wild-type and NNRTI-resistant HIV-1. NNRTIs work by binding to and blocking HIV reverse transcriptase, an HIV enzyme. This prevents HIV from replicating and lowers the amount of HIV in the blood.
References	[1]. Singh K, Marchand B, Rai DK, Sharma B, Michailidis E, Ryan EM, Matzek KB, Leslie MD, Hagedorn AN, Li Z, Norden PR, Hachiya A, Parniak MA, Xu HT, Wainberg MA, Sarafianos SG.Biochemical Mechanism of HIV-1 Resistance to Rilpivirine.J Biol Chem. 2012 Sep 6. [2]. Schafer JJ, Short WR.Rilpivirine, a novel non-nucleoside reverse transcriptase inhibitor for the management of HIV-1 infection: a systematic review.Antivir Ther. 2012 Jul 25. [3]. Vingerhoets J, Rimsky L, Van Eygen V, Nijs S, Vanveggel S, Boven K, Picchio G.Preexisting mutations in the rilpivirine Phase III trials ECHO and THRIVE: prevalence and impact on virologic response.Antivir Ther. 2012 Sep 6. [4]. Gomes T, Juurlink DN, Mamdani MM.Comparative adherence to oxybutynin or tolterodine among older patients.Eur J Clin Pharmacol. 2012 Jan;68(1):97-9. Epub 2011 Jun 28. [5]. Azijn, Hilde et al. TMC278, a next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI), active against wild-type and NNRTI-resistant HIV-1.Antimicrobial Agents and Chemotherapy (2010), 54(2), 718-727.

Density	1.3±0.1 g/cm3
Boiling Point	634.1±65.0 °C at 760 mmHg
Melting Point	245ºC
Molecular Formula	C₂₂H₁₈N₆
Molecular Weight	366.418
Flash Point	337.3±34.3 °C
Exact Mass	366.159302
PSA	97.42000
LogP	3.63
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.665
Storage condition	Refrigerator

Hazard Codes	Xi
HS Code	2933599090

Precursor 9
873-74-5 244768-32-9 24596-19-8 3095-47-4
823786-21-6 708254-90-4 87-62-7 4102-53-8
1228671-28-0
DownStream 1
700361-47-3

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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