149882-10-0

149882-10-0 structure

Name: Lurtotecan
Chemical Name: Lurtotecan
CAS Number: 149882-10-0
Molecular Formula: C₂₈H₃₀N₄O₆
Molecular Weight: 518.56100
Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
Create Date: 2018-09-15 10:32:27
Modify Date: 2024-01-09 07:08:49
Lurtotecan (GI147211; OSI-211), a semisynthetic Camptothecin analog, is a topoisomerase I inhibitor. Lurtotecan has anticancer effects[1].

Name	Lurtotecan
Synonyms	GG 211 11H-1,4-Dioxino(2,3-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-9,12(8H,14H)-dione,8-ethyl-2,3-dihydro-8-hydroxy-15-((4-methyl-1-piperazinyl)methyl)-,(8S) NX 211 (7-(4-methylpiperazinomethylene)-10,11-ethylenedioxy-20(S)-camptothecin) OSI-211 7-[(4-methylpiperazino)methyl]-10,11-(ethylenedioxy)-(20S)-camptothecin

Description	Lurtotecan (GI147211; OSI-211), a semisynthetic Camptothecin analog, is a topoisomerase I inhibitor. Lurtotecan has anticancer effects[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	Topoisomerase I
References	[1]. D L Emerson, et al. In vivo antitumor activity of two new seven-substituted water-soluble camptothecin analogues. Cancer Res. 1995 Feb 1;55(3):603-9.