5976-61-4

5976-61-4 structure

Name: 4-hydroxyestradiol
Chemical Name: 4-hydroxy-17β-estradiol
CAS Number: 5976-61-4
Molecular Formula: C₁₈H₂₄O₃
Molecular Weight: 288.38100
Catalog: analytical chemistry Analytical reagent Ion chromatography reagent
Create Date: 2018-07-05 21:30:30
Modify Date: 2024-01-02 18:27:22
4-Hydroxyestradiol (4-Hydroxy-17β-estradiol) is an endogenous metabolite of Estradiol (HY-B0141). 4-Hydroxyestradiol is carcinogenic and shows mutagenic activity in breast epithelial cells. 4-Hydroxyestradiol inhibits the binding of Estradiol to the estrogen receptor in a competitive manner, with a Ki of 0.48 nM[1][2].

Name	4-hydroxy-17β-estradiol
Synonyms	4-Hydroxy-17β-estradiol MFCD00063335 4-HYDROXYESTRADIOL 4-hydroxy-17beta-estradiol

Description	4-Hydroxyestradiol (4-Hydroxy-17β-estradiol) is an endogenous metabolite of Estradiol (HY-B0141). 4-Hydroxyestradiol is carcinogenic and shows mutagenic activity in breast epithelial cells. 4-Hydroxyestradiol inhibits the binding of Estradiol to the estrogen receptor in a competitive manner, with a Ki of 0.48 nM[1][2].
Related Catalog	Research Areas >> Cancer
References	[1]. Fernandez SV, et al. Estradiol and its metabolites 4-hydroxyestradiol and 2-hydroxyestradiol induce mutations in human breast epithelial cells. Int J Cancer. 2006 Apr 15;118(8):1862-8. doi: 10.1002/ijc.21590. [2]. Van Aswegen CH, et al. Binding of 2-hydroxyestradiol and 4-hydroxyestradiol to estrogen receptors from human breast cancers. J Steroid Biochem. 1989 Apr;32(4):485-92.

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

TOXIC EFFECTS :: Reproductive - Paternal Effects - other effects on male Endocrine - androgenic

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 15,997,1994

Symbol	GHS08
Signal Word	Warning
Hazard Statements	H351
Precautionary Statements	P281
Hazard Codes	Xn
Risk Phrases	40
Safety Phrases	S22;S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	KG7676000