5976-61-4

5976-61-4 structure

Name: 4-hydroxyestradiol
Chemical Name: 4-hydroxy-17β-estradiol
CAS Number: 5976-61-4
Molecular Formula: C₁₈H₂₄O₃
Molecular Weight: 288.38100
Catalog: analytical chemistry Analytical reagent Ion chromatography reagent
Create Date: 2018-07-05 21:30:30
Modify Date: 2026-08-06 19:45:30
4-Hydroxyestradiol (4-Hydroxy-17β-estradiol) is an endogenous metabolite of Estradiol (HY-B0141). 4-Hydroxyestradiol is carcinogenic and shows mutagenic activity in breast epithelial cells. 4-Hydroxyestradiol inhibits the binding of Estradiol to the estrogen receptor in a competitive manner, with a Ki of 0.48 nM[1][2].

Name	4-hydroxy-17β-estradiol
Synonyms	1,3,5-ESTRATRIEN-3,4,17-BETA-TRIOL 1,3,5-Estratriene-3,4,17β-triol 1,3,5-ESTRATRIENE-3,4,17BETA-TRIOL 4-HYDROXY 17-BETA-ESTRADIOL 1, 3, 5-ESTRATRIEN-3, 4, 17β-TRIOL 4-OH-E2α 4-hydroxyestradiol-17beta 4-hydroxy-17beta-estradiol 4-Hydroxy-17-estradiol 4-Hydroxyestradiol-17α 4-Hydroxy-17b-estradiol 4-Hydroxyestradiol,1,3,5-Estratriene-3,4,17β-triol 4-Hydroxy-17β-estradiol Estra-1,3,5-triene-3,4,17-triol, (17β) 4-oh-estradiol estra-1,3,5-triene-3,4,17-beta-triol 3,4,17β-Trihydroxy-,5-Estratriene Estra-1(10),2,4-triene-3,4,17β-triol (17b)-Estra-1,3,5-triene-3,4,17-triol 3,4,17BETA-TRIHYDROXY-1,3,5-ESTRATRIENE MFCD00063335 (17)-Estra-1,3,5-triene-3,4,17-triol Estra-1,3,5-triene-3,4,17α-triol 4-HYDROXYESTRADIOL 4-hydroxyestradiol approx. (hplc)

Description	4-Hydroxyestradiol (4-Hydroxy-17β-estradiol) is an endogenous metabolite of Estradiol (HY-B0141). 4-Hydroxyestradiol is carcinogenic and shows mutagenic activity in breast epithelial cells. 4-Hydroxyestradiol inhibits the binding of Estradiol to the estrogen receptor in a competitive manner, with a Ki of 0.48 nM[1][2].
Related Catalog	Research Areas >> Cancer
References	[1]. Fernandez SV, et al. Estradiol and its metabolites 4-hydroxyestradiol and 2-hydroxyestradiol induce mutations in human breast epithelial cells. Int J Cancer. 2006 Apr 15;118(8):1862-8. doi: 10.1002/ijc.21590. [2]. Van Aswegen CH, et al. Binding of 2-hydroxyestradiol and 4-hydroxyestradiol to estrogen receptors from human breast cancers. J Steroid Biochem. 1989 Apr;32(4):485-92.

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

TOXIC EFFECTS :: Reproductive - Paternal Effects - other effects on male Endocrine - androgenic

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 15,997,1994

Symbol	GHS08
Signal Word	Warning
Hazard Statements	H351
Precautionary Statements	P281
Hazard Codes	Xn
Risk Phrases	40
Safety Phrases	S22;S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	KG7676000