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3131-23-5

3131-23-5 structure
3131-23-5 structure
  • Name: 4-hydroxyestrone
  • Chemical Name: 4-hydroxyestrone
  • CAS Number: 3131-23-5
  • Molecular Formula: C18H22O3
  • Molecular Weight: 286.36500
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2018-07-05 21:46:34
  • Modify Date: 2026-07-01 21:47:50
  • 4-Hydroxyestrone (4-OHE1), an estrone metabolite, has strong neuroprotective effect against oxidative neurotoxicity. 4-Hydroxyestrone increases cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. 4-Hydroxyestrone has little estrogenic activity[1].
Name 4-hydroxyestrone
Synonyms 1,3,5-ESTRATRIENE-3,4-DIOL-17-ONE
4-HYDROXYESTRONE
4-Hydroxy Estrone
(8R,9S,13S,14S)-3,4-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
Estrone Impurity 8
1,3,5-ESTRATRIEN-3,4-DIOL-17-ONE
4-OH-E1
3,4-DIHYDROXY-1,3,5-ESTRATRIEN-17-ONE
(8R,9S,13S,14S)-3,4-Dihydroxy-13-methyl-7,8,9,11,12,13,15,16-octahydro-6H-cyclopenta[a]phenanthren-17(14H)-one
Estrone 4-Hydroxy Impurity
Estra-1,3,5-trien-17-one, 3,4-dihydroxy
5-trien-17-one,3,4-dihydroxy-estra-3
MFCD00079358
3,4-Dihydroxyestra-1,2,4-triene-17-one
3,4-Dihydroxy-1,2,4-estratriene-17-one
4-HydroxyEstrone
3,4-dihydroxyestra-1,3,5-trien-17-one
(9S,14S)-3,4-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
Description 4-Hydroxyestrone (4-OHE1), an estrone metabolite, has strong neuroprotective effect against oxidative neurotoxicity. 4-Hydroxyestrone increases cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. 4-Hydroxyestrone has little estrogenic activity[1].
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Hye Joung Choi, et al. 4-Hydroxyestrone, an Endogenous Estrogen Metabolite, Can Strongly Protect Neuronal Cells Against Oxidative Damage. Sci Rep. 2020 Apr 29;10(1):7283.
Density 1.241g/cm3
Boiling Point 468.2ºC at 760mmHg
Melting Point 260-263ºC
Molecular Formula C18H22O3
Molecular Weight 286.36500
Flash Point 251.1ºC
Exact Mass 286.15700
PSA 57.53000
LogP 3.52300
Index of Refraction 1.61
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KG7749500
CHEMICAL NAME :
Estra-1,3,5(10)-trien-17-one, 3,4-dihydroxy-
CAS REGISTRY NUMBER :
3131-23-5
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C18-H22-O3
MOLECULAR WEIGHT :
286.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
30 mg/kg
SEX/DURATION :
female 1-6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
REFERENCE :
STEDAM Steroids. (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA 94609) V.1- 1963- Volume(issue)/page/year: 30,343,1977
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS KG7749500
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title: CAS No. 3131-23-5 | Chemsrc address: https://m.chemsrc.com/en/baike/754959.html

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