58934-46-6

58934-46-6 structure

Name: N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride
Chemical Name: N-(4-chlorophenyl)-2-phenyl-N-(1-propan-2-ylpiperidin-4-yl)acetamide,hydrochloride
CAS Number: 58934-46-6
Molecular Formula: C₂₂H₂₈Cl₂N₂O
Molecular Weight: 407.37700
Catalog: API Circulatory system medication Antiarrhythmic drug
Create Date: 2019-02-04 19:20:56
Modify Date: 2025-09-01 23:36:56
Lorcainide hydrochloride is a antiarrhythmic agent with local anaesthetic activity. The antiarrhythmic actions of lorcainide are mediated by an impairment of fast sodium conductance. Pharmacologically, this drug appears effective in suppressing reentry phenomena and ectopic pacemaker activity, especially in the ventricles.

Name	N-(4-chlorophenyl)-2-phenyl-N-(1-propan-2-ylpiperidin-4-yl)acetamide,hydrochloride
Synonyms	4'-Chloro-N-(1-isopropyl-4-piperidyl)-2-phenylacetanilide monohydrochloride N-(4-chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl]benzeneacetamide hydrochloride Lorcainide hydrochloride Lorcainide hydrochloride (USAN) Lorcainidhydrochlorid R-15,889

Boiling Point	503ºC at 760 mmHg
Melting Point	263°
Molecular Formula	C₂₂H₂₈Cl₂N₂O
Molecular Weight	407.37700
Flash Point	258ºC
Exact Mass	406.15800
PSA	23.55000
LogP	5.52840

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CY1483700

CHEMICAL NAME :: Benzeneacetamide, N-(4-chlorophenyl)-N-(1-(1-methylethyl)-4-piperidinyl )-, monohydrochloride

CAS REGISTRY NUMBER :: 58934-46-6

LAST UPDATED :: 199009

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C22-H27-Cl-N2-O.Cl-H

MOLECULAR WEIGHT :: 407.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 435 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 18,12,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 22400 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 18,12,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 395 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 18,12,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 19 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 18,12,1982

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
RIDADR	NONH for all modes of transport

63260-75-3

75-26-3

58934-46-6

Literature: Janssen Pharmaceutica N.V. Patent: US4126689 A1, 1978 ; Title/Abstract Full Text Show Details Janssen Pharmaceutica N.V. Patent: US4197304 A1, 1980 ;

Precursor 2
63260-75-3 75-26-3
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