N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride

Modify Date: 2024-04-03 10:01:41

N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride Structure
N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride structure
 Common Name N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride
CAS Number 58934-46-6 Molecular Weight 407.37700
Density N/A Boiling Point 503ºC at 760 mmHg
Molecular Formula C22H28Cl2N2O Melting Point 263°
MSDS USA Flash Point 258ºC
Symbol GHS07
GHS07		 Signal Word Warning

 Use of N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride


Lorcainide hydrochloride is a antiarrhythmic agent with local anaesthetic activity. The antiarrhythmic actions of lorcainide are mediated by an impairment of fast sodium conductance. Pharmacologically, this drug appears effective in suppressing reentry phenomena and ectopic pacemaker activity, especially in the ventricles.

 Names

Name N-(4-chlorophenyl)-2-phenyl-N-(1-propan-2-ylpiperidin-4-yl)acetamide,hydrochloride
Synonym More Synonyms

 Chemical & Physical Properties

Boiling Point 503ºC at 760 mmHg
Melting Point 263°
Molecular Formula C22H28Cl2N2O
Molecular Weight 407.37700
Flash Point 258ºC
Exact Mass 406.15800
PSA 23.55000
LogP 5.52840

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CY1483700
CHEMICAL NAME :
Benzeneacetamide, N-(4-chlorophenyl)-N-(1-(1-methylethyl)-4-piperidinyl )-, monohydrochloride
CAS REGISTRY NUMBER :
58934-46-6
LAST UPDATED :
199009
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C22-H27-Cl-N2-O.Cl-H
MOLECULAR WEIGHT :
407.42

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
435 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 18,12,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
22400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 18,12,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
395 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 18,12,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
19 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 18,12,1982

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
RIDADR NONH for all modes of transport

 Synthetic Route

4-chloro-2-phenyl-N-4-piperidylacetanilide structure

4-chloro-2-phen...

CAS#:63260-75-3

2-Bromopropane structure

2-Bromopropane

CAS#:75-26-3

~%

N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride Structure

N-(4-chlorophen...

CAS#:58934-46-6

Literature: Janssen Pharmaceutica N.V. Patent: US4126689 A1, 1978 ; Title/Abstract Full Text Show Details Janssen Pharmaceutica N.V. Patent: US4197304 A1, 1980 ;

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

4'-Chloro-N-(1-isopropyl-4-piperidyl)-2-phenylacetanilide monohydrochloride
N-(4-chlorophenyl)-N-[1-(1-methylethyl)-4-piperidinyl]benzeneacetamide hydrochloride
Lorcainide hydrochloride
Lorcainide hydrochloride (USAN)
Lorcainidhydrochlorid
R-15,889
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Chemsrc provides CAS#:58934-46-6 MSDS, density, melting point, boiling point, structure, etc. Its name is N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride>> amp version: N-(4-chlorophenyl)-N-(1-isopropyl-4-piperidyl)phenylacetamide monohydrochloride

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