DC Chemicals Limited
China
Product Name: Thio-ITP
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Inosine5'-(tetrahydrogen triphosphate), 6-thio- (9CI)
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Purity: 98.0%
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27652-34-2

27652-34-2 structure

27652-34-2 structure

Name: Thio-ITP
Chemical Name: Inosine 5'-(tetrahydrogen triphosphate), 6-thio
CAS Number: 27652-34-2
Molecular Formula: C₁₀H₁₅N₄O₁₃P₃S
Molecular Weight: 524.23
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2017-06-08 11:23:35
Modify Date: 2024-04-05 10:20:44
Thio-ITP (6-Thioinosine 5′-triphosphate) is a RNA polymerase activities competitive inhibitor[1].

Name	Inosine 5'-(tetrahydrogen triphosphate), 6-thio
Synonyms	O5'-tetrahydroxytriphosphoryl-6-thio-inosine 6-thioinosine-5'-triphosphate 6-Thioinosin-5'-triphosphat 6-Mercaptopurin-ribosid-5'-triphosphat

Description	Thio-ITP (6-Thioinosine 5′-triphosphate) is a RNA polymerase activities competitive inhibitor[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Research Areas >> Endocrinology Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Research Areas >> Others Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Research Areas >> Neurological Disease
In Vitro	Thio-ITP inhibits both endogenous and exogenous DNA-directed RNA synthesis[1]. Thio-ITP has a Ki values whit 40.9±11.0 μM, 38.0±6.47 μM of polymerase I and polymerase II, respectively[1].
References	[1]. [1] Kawahata RT, Chuang LF, Holmberg CA, Osburn BI, Chuang RY. Inhibition of human lymphoma DNA-dependent RNA polymerase activity by 6-mercaptopurine ribonucleoside triphosphate. Cancer Res. 1983 Aug;43(8):3655-9.

Density	2.56g/cm3
Boiling Point	981.2ºC at 760 mmHg
Molecular Formula	C₁₀H₁₅N₄O₁₃P₃S
Molecular Weight	524.23
Flash Point	547.2ºC
Exact Mass	523.95700
PSA	317.53000
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.902

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UP0766000

CHEMICAL NAME :: 9H-Purine-6(1H)-thione, 9-beta-D-ribofuranosyl-, 5'-tetrahydrogen triphosphate

CAS REGISTRY NUMBER :: 27652-34-2

LAST UPDATED :: 198909

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C10-H15-N4-O13-P3-S

MOLECULAR WEIGHT :: 524.26

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 500 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,3655,1983