4321-58-8
4321-58-8 structure
- Name: AMINOCAPROIC ACID HYDROCHLORIDE
- Chemical Name: 6-Aminohexanoic acid hydrochloride
- CAS Number: 4321-58-8
- Molecular Formula: C6H14ClNO2
- Molecular Weight: 167.634
- Catalog: Research Areas Cancer
- Create Date: 2018-08-21 12:05:34
- Modify Date: 2024-01-08 16:39:37
-
6-Aminocaproic acid hydrochloride, a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders[1][2].
| Name | 6-Aminohexanoic acid hydrochloride |
|---|---|
| Synonyms |
6-Aminohexanoic acid hydrochloride (1:1)
6-Aminohexanoic acid hydrochloride Hexanoic acid, 6-amino-, hydrochloride (1:1) 6-aminohexanoic acid,hydrochloride Hexanoic acid, 6-amino-, hydrochloride ε-Aminocaproic acid hydrochloride AMINOCAPROIC ACID HYDROCHLORIDE |
| Description | 6-Aminocaproic acid hydrochloride, a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | 6-Aminocaproic acid hydrochloride (20-180 μg/mL) inhibits fibrinolysis in plasma of Asian elephants, with an effective concentration of 61.5 μg/mL[2]. 6-Aminocaproic acid hydrochloride can be used as a hydrophobic linker to improve near-infrared fluorescence imaging and photothermal cancer therapy of PEGylated indocyanine green[4]. |
| In Vivo | 6-Aminocaproic acid hydrochloride (20-100 mg/kg; a single p.o.) inhibits fibrinolysis at all doses tested in dogs[3]. 6-Aminocaproic acid hydrochloride (20-100 mg/kg; a single p.o.) is rapidly absorbed (Tmax=1 h) and eliminated rapidly in dogs[3]. |
| References |
[1]. Griffin JD, et, al. Epsilon-aminocaproic acid (EACA). Semin Thromb Hemost. Summer 1978;5(1):27-40. |
| Molecular Formula | C6H14ClNO2 |
|---|---|
| Molecular Weight | 167.634 |
| Exact Mass | 167.071304 |
| PSA | 63.32000 |
| LogP | 2.09240 |
| HS Code | 2923900090 |
|---|
|
~94%
4321-58-8 |
| Literature: Effenberger, Franz; Drauz, Karlheinz; Foerster, Siegfried; Mueller, Wolfgang Chemische Berichte, 1981 , vol. 114, # 1 p. 173 - 189 |
|
~94%
4321-58-8 |
| Literature: Effenberger, Franz; Drauz, Karlheinz; Foerster, Siegfried; Mueller, Wolfgang Chemische Berichte, 1981 , vol. 114, # 1 p. 173 - 189 |
|
~%
4321-58-8 |
| Literature: The Procter and Gamble Company Patent: US5520835 A1, 1996 ; |
|
~%
4321-58-8 |
| Literature: Effenberger, Franz; Drauz, Karlheinz; Foerster, Siegfried; Mueller, Wolfgang Chemische Berichte, 1981 , vol. 114, # 1 p. 173 - 189 |
|
~%
4321-58-8 |
| Literature: Novotny, Michal; Hrabalek, Alexandr; Janusova, Barbora; Novotny, Jakub; Vavrova, Katerina Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 9 p. 2726 - 2728 |
|
~%
4321-58-8 |
| Literature: Effenberger, Franz; Drauz, Karlheinz; Foerster, Siegfried; Mueller, Wolfgang Chemische Berichte, 1981 , vol. 114, # 1 p. 173 - 189 |
| Precursor 6 | |
|---|---|
| DownStream 6 | |
| HS Code | 2923900090 |
|---|---|
| Summary | 2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |