AMINOCAPROIC ACID HYDROCHLORIDE

Modify Date: 2024-01-08 16:39:37

AMINOCAPROIC ACID HYDROCHLORIDE Structure
AMINOCAPROIC ACID HYDROCHLORIDE structure
Common Name AMINOCAPROIC ACID HYDROCHLORIDE
CAS Number 4321-58-8 Molecular Weight 167.634
Density N/A Boiling Point N/A
Molecular Formula C6H14ClNO2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AMINOCAPROIC ACID HYDROCHLORIDE


6-Aminocaproic acid hydrochloride, a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders[1][2].

 Names

Name 6-Aminohexanoic acid hydrochloride
Synonym More Synonyms

 AMINOCAPROIC ACID HYDROCHLORIDE Biological Activity

Description 6-Aminocaproic acid hydrochloride, a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders[1][2].
Related Catalog
In Vitro 6-Aminocaproic acid hydrochloride (20-180 μg/mL) inhibits fibrinolysis in plasma of Asian elephants, with an effective concentration of 61.5 μg/mL[2]. 6-Aminocaproic acid hydrochloride can be used as a hydrophobic linker to improve near-infrared fluorescence imaging and photothermal cancer therapy of PEGylated indocyanine green[4].
In Vivo 6-Aminocaproic acid hydrochloride (20-100 mg/kg; a single p.o.) inhibits fibrinolysis at all doses tested in dogs[3]. 6-Aminocaproic acid hydrochloride (20-100 mg/kg; a single p.o.) is rapidly absorbed (Tmax=1 h) and eliminated rapidly in dogs[3].
References

[1]. Griffin JD, et, al. Epsilon-aminocaproic acid (EACA). Semin Thromb Hemost. Summer 1978;5(1):27-40.

[2]. Kaye S, et, al. EFFECT OF ε-AMINOCAPROIC ACID ON FIBRINOLYSIS IN PLASMA OF ASIAN ELEPHANTS (ELEPHAS MAXIMUS). J Zoo Wildl Med. 2016 Jun;47(2):397-404.

[3]. Brown JC, et, al. Effect of aminocaproic acid on clot strength and clot lysis of canine blood determined by use of an in vitro model of hyperfibrinolysis. Am J Vet Res. 2016 Nov;77(11):1258-1265.

[4]. Hu Q, et al. 6-Aminocaproic acid as a linker to improve near-infrared fluorescence imaging and photothermal cancer therapy of PEGylated indocyanine green. Colloids Surf B Biointerfaces. 2021 Jan;197:111372.

 Chemical & Physical Properties

Molecular Formula C6H14ClNO2
Molecular Weight 167.634
Exact Mass 167.071304
PSA 63.32000
LogP 2.09240

 Safety Information

HS Code 2923900090

 Customs

HS Code 2923900090
Summary 2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

 Synonyms

6-Aminohexanoic acid hydrochloride (1:1)
6-Aminohexanoic acid hydrochloride
Hexanoic acid, 6-amino-, hydrochloride (1:1)
6-aminohexanoic acid,hydrochloride
Hexanoic acid, 6-amino-, hydrochloride
ε-Aminocaproic acid hydrochloride
AMINOCAPROIC ACID HYDROCHLORIDE