25371-96-4

25371-96-4 structure

Name: 1-(2-(trifluoromethyl)phenyl)-1h-imidazole
Chemical Name: 1-[2-(trifluoromethyl)phenyl]imidazole
CAS Number: 25371-96-4
Molecular Formula: C₁₀H₇F₃N₂
Molecular Weight: 212.171
Create Date: 2018-09-25 17:25:09
Modify Date: 2025-08-21 12:00:02
TRIM is a potent nitric oxide synthase inhibitor. TRIM inhibits mouse cerebellar nNOS and rat lung iNOS in vitro with IC50 values of 28.2 and 27.0 µM, respectively. Antidepressant- and anxiolytic-like effects[1][2].

Name	1-[2-(trifluoromethyl)phenyl]imidazole
Synonyms	1-[2-(Trifluoromethyl)phenyl]-1H-imidazole 1-(2-(trifluoromethyl)phenyl)-1h-imidazole 1-[2-(Trifluoromethyl)phenyl]imidazole Trim MFCD00041206 1H-Imidazole, 1-[2-(trifluoromethyl)phenyl]- 1H-Imidazole, 1-(2-(trifluoromethyl)phenyl)-

Description	TRIM is a potent nitric oxide synthase inhibitor. TRIM inhibits mouse cerebellar nNOS and rat lung iNOS in vitro with IC50 values of 28.2 and 27.0 µM, respectively. Antidepressant- and anxiolytic-like effects[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Neurological Disease
In Vitro	TRIM is a relatively weak inhibitor of eNOS (IC50, 1057.5 µM)[1].
References	[1]. Handy RL, et al. The antinociceptive effect of 1-(2-trifluoromethylphenyl) imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse. Br J Pharmacol. 1995;116(5):2349-2350. [2]. Volke V, et al. Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice. Behav Brain Res. 2003;140(1-2):141-147.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2933290090

HS Code	2933290090
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%