1-(2-(trifluoromethyl)phenyl)-1h-imidazole
1-(2-(trifluoromethyl)phenyl)-1h-imidazole structure
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Common Name | 1-(2-(trifluoromethyl)phenyl)-1h-imidazole | ||
|---|---|---|---|---|
| CAS Number | 25371-96-4 | Molecular Weight | 212.171 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 288.3±40.0 °C at 760 mmHg | |
| Molecular Formula | C10H7F3N2 | Melting Point | 43 °C | |
| MSDS | USA | Flash Point | 128.2±27.3 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of 1-(2-(trifluoromethyl)phenyl)-1h-imidazoleTRIM is a potent nitric oxide synthase inhibitor. TRIM inhibits mouse cerebellar nNOS and rat lung iNOS in vitro with IC50 values of 28.2 and 27.0 µM, respectively. Antidepressant- and anxiolytic-like effects[1][2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 1-[2-(trifluoromethyl)phenyl]imidazole |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | TRIM is a potent nitric oxide synthase inhibitor. TRIM inhibits mouse cerebellar nNOS and rat lung iNOS in vitro with IC50 values of 28.2 and 27.0 µM, respectively. Antidepressant- and anxiolytic-like effects[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | TRIM is a relatively weak inhibitor of eNOS (IC50, 1057.5 µM)[1]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 288.3±40.0 °C at 760 mmHg |
| Melting Point | 43 °C |
| Molecular Formula | C10H7F3N2 |
| Molecular Weight | 212.171 |
| Flash Point | 128.2±27.3 °C |
| Exact Mass | 212.056137 |
| PSA | 17.82000 |
| LogP | 2.55 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.522 |
| InChIKey | WZBWBNCQUTXYEL-UHFFFAOYSA-N |
| SMILES | FC(F)(F)c1ccccc1-n1ccnc1 |
| Storage condition | 2-8°C |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2933290090 |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2933290090 |
|---|---|
| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Magnetic high throughput screening system for the development of nano-sized molecularly imprinted polymers for controlled delivery of curcumin.
Analyst 140(9) , 3113-20, (2015) Curcumin is a versatile anti-inflammatory and anti-cancer agent known for its low bioavailability, which could be improved by developing materials capable of binding and releasing drug in a controlled... |
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Cholesterol-based polymeric monolithic columns for capillary liquid chromatography.
J. Chromatogr. A. 1373 , 114-23, (2014) A novel, cholesterol-based polymeric monolithic stationary phase for capillary liquid chromatography, was prepared by thermally initiated in-situ polymerization. Cholesteryl methacrylate (CholMA) was ... |
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Robust naphthyl methacrylate monolithic column for high performance liquid chromatography of a wide range of solutes.
J. Chromatogr. A. 1409 , 166-72, (2015) An organic monolithic column based on the co-polymerization of 2-naphthyl methacrylate (NAPM) as the functional monomer and trimethylolpropane trimethacrylate (TRIM) as the crosslinker was introduced ... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1266185
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Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
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Name: Tocris HTS for Inhibitors of Aerobactin Synthetase lucA
Source: 23265
External Id: IucA Pilot Assay Tocris Library
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
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Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01
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Name: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen
Source: NCGC
Target: N/A
External Id: SMAD3201
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Name: uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay
Source: Burnham Center for Chemical Genomics
Target: cystic fibrosis transmembrane conductance regulator [Homo sapiens]
External Id: SBCCG-A764-CF-PAF-Primary-Assay
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ant...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_ANT_FLUO8_1536_1X%INH PRUN
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 1-[2-(Trifluoromethyl)phenyl]-1H-imidazole |
| 1-(2-(trifluoromethyl)phenyl)-1h-imidazole |
| 1-[2-(Trifluoromethyl)phenyl]imidazole |
| Trim |
| MFCD00041206 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the molecular formula of 1-[2-(trifluoromethyl)phenyl]imidazole? |
| A: Molecular formula of 1-[2-(trifluoromethyl)phenyl]imidazole is C10H7F3N2. |
| Q: What are the uses of 1-[2-(trifluoromethyl)phenyl]imidazole? |
| A: Main uses of 1-[2-(trifluoromethyl)phenyl]imidazole: TRIM is a potent nitric oxide synthase inhibitor. TRIM inhibits mouse cerebellar nNOS and rat lung iNOS in vitro with IC50 values of 28.2 and 27.0 µM, respectively. Antidepressant- and anxiolytic-like effects[1][2]. |
| Q: What are the storage conditions for 1-[2-(trifluoromethyl)phenyl]imidazole? |
| A: Storage conditions for 1-[2-(trifluoromethyl)phenyl]imidazole: 2-8°C. |
| Q: What is the molecular weight of 1-[2-(trifluoromethyl)phenyl]imidazole? |
| A: Molecular weight of 1-[2-(trifluoromethyl)phenyl]imidazole is 212.171. |
| Q: What is the LogP of 1-[2-(trifluoromethyl)phenyl]imidazole? |
| A: LogP of 1-[2-(trifluoromethyl)phenyl]imidazole is 2.55. |
| Q: What is the boiling point of 1-[2-(trifluoromethyl)phenyl]imidazole? |
| A: Boiling point of 1-[2-(trifluoromethyl)phenyl]imidazole is 288.3±40.0 °C at 760 mmHg. |
| Q: What is the InChIKey of 1-[2-(trifluoromethyl)phenyl]imidazole? |
| A: InChIKey of 1-[2-(trifluoromethyl)phenyl]imidazole is WZBWBNCQUTXYEL-UHFFFAOYSA-N. |
| Q: What is the CAS number of 1-[2-(trifluoromethyl)phenyl]imidazole? |
| A: CAS number of 1-[2-(trifluoromethyl)phenyl]imidazole is 25371-96-4. |
| Q: What is the polar surface area (PSA) of 1-[2-(trifluoromethyl)phenyl]imidazole? |
| A: Polar surface area (PSA) of 1-[2-(trifluoromethyl)phenyl]imidazole is 17.82000. |
| Q: What is the safety information for 1-[2-(trifluoromethyl)phenyl]imidazole? |
| A: Safety information for 1-[2-(trifluoromethyl)phenyl]imidazole: S26-S36. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |