Shanghai Nianxing Industrial Co., Ltd
China
Product Name: (2E)-(2H2)-2-Butenedioic acid
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Purity: 98.0%
Stocking Period: 10 Day
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24461-32-3

24461-32-3 structure

24461-32-3 structure

Name: (2E)-(2H2)-2-Butenedioic acid
Chemical Name: (E)-2,3-dideuteriobut-2-enedioic acid
CAS Number: 24461-32-3
Molecular Formula: C₄H₂D₂O₄
Molecular Weight: 118.085
Create Date: 2018-02-24 08:00:00
Modify Date: 2024-01-11 20:50:58
Fumaric acid-d2 is the deuterium labeled Fumaric acid[1]. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite[2].

Name	(E)-2,3-dideuteriobut-2-enedioic acid
Synonyms	(2E)-(H)-2-Butenedioic acid (2E)-(H)But-2-enedioic acid 2,3-dideuterio-fumaric acid Fumaric acid-2,3-d2 2,3-2H-fumaric acid 2-Butenedioic-2,3-d acid, (2E)- Maleic acid-2,3-d2 2,3-Dideuterio-fumarsaeure MFCD00144378

Description	Fumaric acid-d2 is the deuterium labeled Fumaric acid[1]. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite[2].
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Whelan DT, et al. Fumaric aciduria: a new organic aciduria, associated with mental retardation and speech impairment. Clin Chim Acta. 1983 Aug 31;132(3):301-8.

Density	1.5±0.1 g/cm3
Boiling Point	355.5±25.0 °C at 760 mmHg
Melting Point	299-300ºC (subl.)(lit.)
Molecular Formula	C₄H₂D₂O₄
Molecular Weight	118.085
Flash Point	183.0±19.7 °C
Exact Mass	118.023514
PSA	74.60000
LogP	-0.01
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.526
Storage condition	2-8°C

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319
Precautionary Statements	P305 + P351 + P338
Hazard Codes	Xi
Risk Phrases	R41;R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport

23057-98-9 structure

23057-98-9

~90%

24461-32-3 structure

24461-32-3

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 10 p. 2387 - 2392

63995-70-0 structure

63995-70-0

142-45-0 structure

142-45-0

~89%

24461-32-3 structure

24461-32-3

98511-67-2 structure

98511-67-2

Literature: Tetrahedron, , vol. 46, # 18 p. 6381 - 6398

142-45-0 structure

142-45-0

~%

24461-32-3 structure

24461-32-3

Literature: European Journal of Organic Chemistry, , # 2 p. 387 - 401

Precursor 3
23057-98-9 63995-70-0 142-45-0
DownStream 0