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24461-32-3

24461-32-3 structure
24461-32-3 structure
  • Name: (2E)-(2H2)-2-Butenedioic acid
  • Chemical Name: (E)-2,3-dideuteriobut-2-enedioic acid
  • CAS Number: 24461-32-3
  • Molecular Formula: C4H2D2O4
  • Molecular Weight: 118.085
  • Create Date: 2018-02-24 08:00:00
  • Modify Date: 2024-01-11 20:50:58
  • Fumaric acid-d2 is the deuterium labeled Fumaric acid[1]. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite[2].
Name (E)-2,3-dideuteriobut-2-enedioic acid
Synonyms (2E)-(H)-2-Butenedioic acid
(2E)-(H)But-2-enedioic acid
2,3-dideuterio-fumaric acid
Fumaric acid-2,3-d2
2,3-2H-fumaric acid
2-Butenedioic-2,3-d acid, (2E)-
Maleic acid-2,3-d2
2,3-Dideuterio-fumarsaeure
MFCD00144378
Description Fumaric acid-d2 is the deuterium labeled Fumaric acid[1]. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite[2].
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Whelan DT, et al. Fumaric aciduria: a new organic aciduria, associated with mental retardation and speech impairment. Clin Chim Acta. 1983 Aug 31;132(3):301-8.  

Density 1.5±0.1 g/cm3
Boiling Point 355.5±25.0 °C at 760 mmHg
Melting Point 299-300ºC (subl.)(lit.)
Molecular Formula C4H2D2O4
Molecular Weight 118.085
Flash Point 183.0±19.7 °C
Exact Mass 118.023514
PSA 74.60000
LogP -0.01
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.526
Storage condition 2-8°C
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319
Precautionary Statements P305 + P351 + P338
Hazard Codes Xi
Risk Phrases R41;R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
23057-98-9 structure

23057-98-9

~90%

24461-32-3 structure

24461-32-3

Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 10 p. 2387 - 2392
63995-70-0 structure

63995-70-0

142-45-0 structure

142-45-0

~89%

24461-32-3 structure

24461-32-3

98511-67-2 structure

98511-67-2

Literature: Tetrahedron, , vol. 46, # 18 p. 6381 - 6398
142-45-0 structure

142-45-0

~%

24461-32-3 structure

24461-32-3

Literature: European Journal of Organic Chemistry, , # 2 p. 387 - 401
Precursor  3

DownStream  0


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title: CAS No. 24461-32-3 | Chemsrc address: https://m.chemsrc.com/en/baike/684612.html

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